The paper addresses the problem of imaginative resistance in science, that is, why and under what circumstances imagination sometimes resists certain scenarios. In the first part, the paper presents and discusses two accounts concerning the problem and relevant for the main thesis of this study. The first position is that of Gendler (Journal of Philosophy 97:55–81, 2000), (Gendler, in: Nichols (ed) The Architecture of the Imagination: New essays on pretence, possibility and fiction, Oxford University Press, New York, 2006a), (Gendler & (...) Liao, in: Gibson, Carroll (eds) The routledge companion to philosophy of literature, Routledge, New York, 2016), according to which imaginative resistance mainly concerns evaluative scenarios, presenting deviant moral attitudes. The second account examined is that of Kim et al. (in: Cova, Réhault (eds) Advances in experimental philosophy of aesthetics, Bloomsbury, London, 2018), who insisted on the link between imaginative resistance on the one hand and counterfactual and counterdescriptive scenarios on the other. In the light of both theories, this paper discusses the importance of addressing the problem of imaginative resistance in the scientific enterprise in the light of some mechanisms of embodied simulation, based on the activity of mirror neurons and investigated within the framework of the Embodied Simulation Theory. (shrink)