Immunologists use psychological and cognitive terms to describe and explain the behavior of our immune system. Do they use them metaphorically or literally? In this paper I show that on the grounds of some psychophysical assumptions, the uniqueness of each person as an individual organism necessarily corresponds to the singularity of each person as a psychological subject. On the basis of these assumptions, immunologists, irrespective of their various conceptual frames, are entitled to ascribe psychological and cognitive traits to our immune (...) system and its behavior. Immunologists are allowed to do so because each immune system of any higher, unique individual organism corresponds to psychological traits, which are ascribable only to persons, each of whom is a singular being. This correspondence is necessarily compatible with the psychophysical unity or inseparability. Furthermore, the psychological or cognitive traits pertain to the immune system require no consciousness. In the case of artificial immune systems, in contrast, the application of psychological or cognitive terms is only metaphorical, for each such system is not unique but it is duplicable or replicable. Only the immune system of unique individual organisms that as psychological subjects are singular beings—i.e. persons—can be subject, literally or non-metaphorically, to psychological and cognitive terms. (shrink)

We argue that mesoscale ecosystem resilience shifts akin to sudden phase transitions in physical systems can entrain similarly punctuated events of gene expression on more rapid time scales, and, in part through such means, slower changes induced by selection pressure, triggering punctuated Darwinian evolutionary transitions on geologic time scales. The approach reduces ecosystem, gene expression, and Darwinian genetic dynamics to a least common denominator of information sources interacting by crosstalk at markedly different rates. Pettini's 'topological hypothesis', via a homology between (...) information source uncertainty and free energy density, generates a statistical model of sudden coevolutionary phase transition based on the Rate Distortion and Shannon-McMillan Theorems of information theory which links all three levels. Holling's (1992) extended keystone hypothesis regarding the particular role of mesoscale phenomena in entraining both slower and faster dynamical structures produces the result. A main theme is the necessity of a cognitive paradigm for gene expression, mirroring I. Cohen's cognitive approach to immune function. Invocation of the necessary conditions imposed by the asymptotic limit theorems of communication theory enables us to penetrate one layer more deeply before needing to impose a phenomenological system of 'Onsager relation' recursive stochastic differential equations. Extending the development to second order via a large deviations argument may permit modeling the influence of human cultural structures on ecosystems. (shrink)

Applying a necessary condition communication theory formalism roughly similar to that of Dretske, but focused entirely on the statistical properties of long sequences of signals emitted by the interacting cognitive modules of human biology, we explore the regularities apparent in comorbid psychiatric and chronic physical disorders using an extension of recent perspectives on autoimmune disease. We find that structured psychosocial stress can literally write a distorted image of itself onto child development, resulting in a life course trajectory to characteristic forms (...) of comorbid mind/body dysfunction affecting both dominant and subordinate populations within a pathogenic social hierarchy. (shrink)

Adapting Dretske's approach on the necessary conditions for mental process, we apply a communication theory analysis of interacting cognitive biological and social modules to the global neuronal workspace, the emerging standard model for consciousness. Using an obvious canonical homology with statistical physics, the method, when iterated, generates a fluctuating dynamic threshold recognizably similar to phase transition in a physical system, but constrained to a manifold/atlas structure analogous to a tunable retina. The resulting 'General Cognitive Model' can be extended in a (...) straightforward manner to include the effects of psychosocial stress, culture, or other cognitive modules which constitute a structured, embedding hierarchy of contextual constraints acting at a slower rate than neuronal function itself. This produces a 'biopsychosociocultural' treatment of consciousness that, while otherwise remarkably similar to the standard development, meets compelling philosophical and other objections to brain-only descriptions. (shrink)

[Przekład] W artykule dokonano przeglądu historiografii immunologii od 1999 roku, co w pewnym stopniu jest odpowiedzią na stanowisko takich historyków jak Thomas Söderqvist, którzy twierdzili, że to pole badawcze nie było wówczas dość rozwinięte (Söderqvist i Stillwell). Najpierw wskazano przeszłe i teraźniejsze problemy, które historiografia ma ze zdefiniowaniem immunologii, a następnie skomentowano ostatnie studia nad pojęciem immunologicznego „ja”. W dalszym toku przeglądu przeanalizowano i oceniono nowe publikacje poświęcone zróżnicowanym zagadnieniom immunologii oraz niektóre charakterystyczne oskarżenia formułowane wobec niedostatku pewnych dziedzin historii, (...) na przykład historii biograficznych i historii instytucji. W podsumowaniu przedstawiono konkurujące ze sobą kierunki, w których rozwinęła się historia immunologii, wychodząc poza wstępne, tymczasowe stadia uchwycone w poprzednim przeglądzie, i stając się wielogłosową, pluripotencjalną dyscypliną, podobną do przedmiotu jej badań. Pokazano też, że historia immunologii nadal rozwija się na wiele nowych i ekscytujących sposobów. (shrink)