We are living in a time of unprecedented challenges: human activity is now the primary driver shaping the planet and we are perilously close to breaching a variety of critical planetary boundaries—a prelude to the possible extinction of our species. How should we be thinking and acting—as persons, communities, institutions and societies—so as to best understand and respond to these challenges? What contribution can the field of science and religion make to develop the knowledge needed to negotiate the civilizational transition (...) we face? Such questions were addressed through a series of dialogues at the 62nd annual conference of the Institute on Religion in an Age of Science in June of 2016—“How Can We Know? Co-Creating Knowledge in Perilous Times.” This essay sets the background to these challenges and introduces the set of articles in this themed section. (shrink)