This essay examines the early career of the chemist Emil Erlenmeyer (1825–1909), focusing on his various endeavors in industrial consulting and entrepreneurship, and his eventual decisive turn, in 1862, to academic research and teaching. This case study offers insights into the developing relationship between theory-based academic research and artisanal and industrial practice in the German states during the 1850s and 1860s. Attention is paid to the relevance of this material to the contemporary historiography of “technoscience.”.