Since the early 20th century underdetermination has been one of the most contentious problems in the philosophy of science. In this article I relate the underdetermination problem to models in biology and defend two main lines of argument: First, the use of models in this discipline lends strong support to the underdetermination thesis. Second, models and theories in biology are not determined strictly by the logic of representation of the studied phenomena, but also by other constraints such as research traditions, (...) backgrounds of the scientists, aims of the research and available technology. Convincing evidence for the existence of underdetermination in biology, where models abound, comes both from the fact that for a natural phenomenon we can create a number of candidate models but also from the fact that we do not have a universal rule that would adjudicate among them. This all makes a strong case for the general validity of underdetermination thesis. (shrink)

Traditional analyses of the curve fitting problem maintain that the data do not indicate what form the fitted curve should take. Rather, this issue is said to be settled by prior probabilities, by simplicity, or by a background theory. In this paper, we describe a result due to Akaike [1973], which shows how the data can underwrite an inference concerning the curve's form based on an estimate of how predictively accurate it will be. We argue that this approach throws light (...) on the theoretical virtues of parsimoniousness, unification, and non ad hocness, on the dispute about Bayesianism, and on empiricism and scientific realism. * Both of us gratefully acknowledge support from the Graduate School at the University of Wisconsin-Madison, and NSF grant DIR-8822278 (M.F.) and NSF grant SBE-9212294 (E.S.). Special thanks go to A. W. F. Edwards.William Harper. Martin Leckey. Brian Skyrms, and especially Peter Turney for helpful comments on an earlier draft. (shrink)

The idea that simplicity matters in science is as old as science itself, with the much cited example of Ockham's Razor, 'entia non sunt multiplicanda praeter necessitatem': entities are not to be multiplied beyond necessity. A problem with Ockham's razor is that nearly everybody seems to accept it, but few are able to define its exact meaning and to make it operational in a non-arbitrary way. Using a multidisciplinary perspective including philosophers, mathematicians, econometricians and economists, this 2002 monograph examines simplicity (...) by asking six questions: what is meant by simplicity? How is simplicity measured? Is there an optimum trade-off between simplicity and goodness-of-fit? What is the relation between simplicity and empirical modelling? What is the relation between simplicity and prediction? What is the connection between simplicity and convenience? The book concludes with reflections on simplicity by Nobel Laureates in Economics. (shrink)

The philosophical significance of the procedure of applying Akaike Information Criterion (AIC) to curve-fitting problems is evaluated. The theoretical justification for using AIC (the so-called Akaike's theorem) is presented in a rigorous way, and its range of validity is assessed by presenting both instances in which it is valid and counter-examples in which it is invalid. The philosophical relevance of the justification that this result gives for making one particular choice between simple and complicated hypotheses is emphasized. In addition, recent (...) claims that the methods based on Akaike's theorem are relevant to other philosophical problems associated with the notion of simplicity are presented and evaluated. (shrink)

Conflicting results undermine making inferences from the empirical literature. So far, the replication crisis is mainly seen as resulting from honest errors and questionable research practices such as p-hacking or the base-rate fallacy. I discuss the malleability (researcher degrees of freedom) of quantitative research and argue that conflicting results can emerge from two studies using different but plausible designs (e.g., eligibility criteria, operationalization of concepts, outcome measures) and statistical methods. I also explore how the choices regarding study design and statistical (...) techniques bias results in a way that makes them more or less relevant for a given policy or clinical question. (shrink)

In this paper I will argue that, in general, where the evidence supports two theories equally, the simpler theory is not more likely to be true and is not likely to be nearer the truth. In other words simplicity does not tell us anything about model bias. Our preference for simpler theories (apart from their obvious pragmatic advantages) can be explained by the facts that humans are known to elaborate unsuccessful theories rather than attempt a thorough revision and that a (...) fixed set of data can only justify adjusting a certain number of parameters to a limited degree of precision. No extra tendency towards simplicity in the natural world is necessary to explain our preference for simpler theories. Thus Occam's razor eliminates itself (when interpreted in this form). (shrink)

In the curve fitting problem two conflicting desiderata, simplicity and goodness-of-fit, pull in opposite directions. To this problem, we propose a solution that strikes a balance between simplicity and goodness-of-fit. Using Bayes’ theorem we argue that the notion of prior probability represents a measurement of simplicity of a theory, whereas the notion of likelihood represents the theory’s goodness-of-fit. We justify the use of prior probability and show how to calculate the likelihood of a family of curves. We diagnose the relationship (...) between simplicity of a theory and its predictive accuracy. (shrink)