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  1. Oncogenesis as a Selective Force: Adaptive Evolution in the Face of a Transmissible Cancer.Tracey Russell, Thomas Madsen, Frédéric Thomas, Nynke Raven, Rodrigo Hamede & Beata Ujvari - 2018 - Bioessays 40 (3):1700146.
    Similar to parasites, malignant cells exploit the host for energy, resources and protection, thereby impairing host health and fitness. Although cancer is widespread in the animal kingdom, its impact on life history traits and strategies have rarely been documented. Devil facial tumour disease, a transmissible cancer, afflicting Tasmanian devils, provides an ideal model system to monitor the impact of cancer on host life-history, and to elucidate the evolutionary arms-race between malignant cells and their hosts. Here we provide an overview of (...)
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  • Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.Tazzio Tissot, Audrey Arnal, Camille Jacqueline, Robert Poulin, Thierry Lefèvre, Frédéric Mery, François Renaud, Benjamin Roche, François Massol, Michel Salzet, Paul Ewald, Aurélie Tasiemski, Beata Ujvari & Frédéric Thomas - 2016 - Bioessays 38 (3):276-285.
    Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...)
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