We assess the arguments for recognising functionally integrated multispecies consortia as genuine biological individuals, including cases of so-called ‘holobionts’. We provide two examples in which the same core biochemical processes that sustain life are distributed across a consortium of individuals of different species. Although the same chemistry features in both examples, proponents of the holobiont as unit of evolution would recognize one of the two cases as a multispecies individual whilst they would consider the other as a compelling case of (...) ecological dependence between separate individuals. Some widely used arguments in support of the ‘holobiont’ concept apply equally to both cases, suggesting that those arguments have misidentified what is at stake when seeking to identify a new level of biological individuality. One important aspect of biological individuality is evolutionary individuality. In line with other work on the evolution of individuality, we show that our cases can be distinguished by focusing on the fitness alignment between the partners of the consortia. We conclude that much of the evidence currently presented for the ubiquity and importance of multi-species individuals is simply not to the point, at least unless the issue of biological individuality is firmly divorced from the question of evolutionary individuality. (shrink)

Riassunto: Nell’ambito delle associazioni simbiotiche ha acquisito credito crescente la cosiddetta prospettiva “olobiontica”, secondo cui animali e piante non dovrebbero più essere considerati entità autonome, con confini chiaramente delimitati, ma li si dovrebbe vedere come unità funzionali che consistono di reti inter-relazionali tra specie diverse. In quest’ottica le funzioni precedentemente attribuite a un singolo componente devono essere riviste alla luce della prospettiva relazionale e considerate quindi come prodotto di un’unità funzionale, ossia dell’olobionte. Nella prospettiva funzionalista, il noto concetto di mente (...) estesa considera la possibilità per cui il veicolo della cognizione possa andare oltre il cervello e anche oltre i limiti del corpo, mediante dispositivi artificiali. Questo lavoro intende offrire una variante della teoria della mente estesa intesa non solo come possibilità teoretica ma anche come ipotesi compatibile con alcuni recenti sviluppi nella ricerca biologica e biomedica. Si sosterrà quindi che l’attività del microbiota umano svolgono un ruolo funzionale nella regolazione dei nostri processi cognitivi, suggerendo che il microbiota costituisce un’estensione funzionale del sistema cognitivo precedentemente descritto come “umano”. La revisione e l’estensione dell’individuo biologico in favore dell’olobionte come unità funzionale porta anche alla necessità di aggiornare i confini dell’individuo come agente cognitivo. Parole chiave: Microbiota; Cognizione estesa; Olobionte; Simbiosi; Funzionalismo The individuated extended mind: A symbiotic perspective: In the framework of symbiotic associations, the so-called “holobiontic” perspective has increasingly emerged, according to which animals and plants should no longer be considered as autonomous entities, delimited by clear boundaries, but should rather be seen as functional units, consisting of inter-relational networks of different species. From this perspective, the functions that were previously ascribed to a single component, must be updated in the light of this relational perspective and rather judged as a product of the functional unit, that is, the holobiont. In a functionalist perspective, the famous conception of the extended mind investigates the hypothesis that the vehicle of cognition can extend not only outside the brain but also beyond the limits of the body, through artificial devices. The present work aims to offer a variant of the extended theory of mind not only as a theoretical possibility but also in accordance with some recent developments in biological and biomedical research. It will therefore be argued that the activity of the human microbiota plays a functional role in the regulation of our cognitive processes suggesting that the microbiota constitutes a functional extension of the cognitive system previously described as “human”. The revision and extension of the biological individual in favor of the holobiont as a functional unit also leads to the need to update the boundaries of the individual as a cognitive agent. Keywords: Microbiota; Extended Cognition; Holobiont; Symbiosis; Functionalism. (shrink)

Autonomy isn't going anywhere. Yet challenges to autonomy's place of privilege atop the mantle of bioethics are similarly perennial. From our perspective, the emerging literature of microbial biolo...

In the theory and history of ecology, Frederic Clements’s theory of plant communities is usually presented as the historical prototype and a paradigmatic example of synecological organicism, characterised by the assumption that ecological communities are functionally integrated units of mutually dependent species. In this paper, I will object to this standard interpretation of Clements’s theory. Undoubtedly, Clements compares plant communities with organisms and calls them “complex organisms” and “superorganisms”. Further, he can indeed be regarded as a proponent of ecological organicism—provided (...) that one defines ecological organicism as the interpretation of synecological units according to the model of the individual organism. However, Clements’s theory does not include the assumption that mutual dependence is a principle of the organisation of plant communities. Rather, he interprets plant communities as top-down control-hierarchical entities, in which subordinate species depend on dominant species—but not the other way around. Therefore, his theory represents what may be called ‘control-hierarchical organicism’ as against ‘mutualistic organicism’. The erroneous attribution to Clements of ‘mutualistic organicism’ might be due to an unawareness of the existence of different concepts of the organism. This unawareness results in the projection on Clements’s theory of a seemingly self-evident mutualistic concept of organism that Clements himself did not use as a basis for his theory of plant communities. (shrink)

Evolution by natural selection has been extended to several supraorganismic levels, but whether it can apply to ecosystems remains controversial on two main counts. First, local ecosystems are loosely individuated, so that it is unclear how they manifest heredity and fitness. Second, even if they did, the meta-ecosystem formed by this population of local ecosystems will also suffer from a very low degree of cohesion, which will jeopardize any ENS. We suggest a way to overcome both issues, focusing on ecosystem (...) properties rather than on ecosystemic individuals. First, we follow recent theoretical developments which deny the centrality of reproduction in ENS. This leads us to merge heredity and fitness in a single process, in which a local ecosystem causally influences its neighbors, in a way responsible for their phenotypic similarity. Second, we suggest that the resulting meta-ecosystem need not meet the criteria of individuality. Instead, the evolving meta-ecosystem is best understood as a homeostatic property cluster, i.e., a set of phenotypes that together evolve by ENS at the ecosystem level. We illustrate this conceptual framework with a hypothetical example of local ecosystems that vary in terms of stability, productivity, diversity, and complementarity between species. Finally, we stress that our property-based account of ecosystemic ENS can help understand evolution at other biological levels, such as early life evolution and holobionts. (shrink)

Cancer biology features the ascription of normal functions to parts of cancers. At least some ascriptions of function in cancer biology track local normality of parts within the global abnormality of the aberration to which those parts belong. That is, cancer biologists identify as functions activities that, in some sense, parts of cancers are supposed to perform, despite cancers themselves having no purpose. The present paper provides a theory to accommodate these normal function ascriptions—I call it the Modeling Account of (...) Normal Function (MA). MA comprises two claims. First, normal functions are activities whose performance by the function-bearing part contributes to the self-maintenance of the whole system and, thereby, results in the continued presence of that part. Second, MA holds that models of system-level activities that are (partly) constitutive of self-maintenance are improved by including a representation of the relevant function-bearing part and by making reference to the activity/activities that part performs which contribute(s) to those system-level activities. I contrast MA with two other accounts that seek to explicate the ascription of normal functions in biology, namely, the organizational account and the selected effects account. Both struggle to extend to cancer biology. However, I offer ecumenical readings which allow them to recover some ascriptions of normal function to parts of cancers. So, though I contend that MA excels in this respect, the purpose of this paper is served if it provides materials for bridging the gap between cancer biology, philosophy of cancer, and the literature on function. (shrink)

Philosophy of immunology is a subfield of philosophy of biology dealing with ontological and epistemological issues related to the studies of the immune system. While speculative investigations and abstract analyses have always been part of immune theorizing, until recently philosophers have largely ignored immunology. Yet the implications for understanding the philosophical basis of organismal functions framed by immunity offer new perspectives on fundamental questions of biology and medicine. Developed in the context of history of medicine, theoretical biology, and medical anthropology, (...) philosophy of immunology differs from these related branches of study in its focus on traditional philosophical questions concerning identity, individuality, ecology, cognition, scientific methodology and theory construction. This broad agenda derives from immunology’s multifaceted research program that has developed from its initial clinical challenges of host defense, transplantation, autoimmunity, tumor immunology, and allergy. In addition to these well-established research areas, immunity is now understood to play a central role in other physiological functions, development, ecology, and evolutionary mechanics. Holding together these diverse domains of inquiry lie philosophical commitments oriented by organismal identity. In this regard, pertinent issues are raised concerning cognition (organization of immune perception and information processing), the character of individuality (framed by the ecological context of immune-mediated assimilation and rejection), and the dynamics of complex systems (understood as holistic systems biology). Indeed, immunology, in the context of cognitive science, evolutionary biology, environmental sciences, and development provides multi-focal perspectives for philosophy of science. (shrink)