This perspective examines the role of chemistry and molecular biology for a science of consciousness. Opposed to the consensus view, we argue that the molecular organization of biological systems is key to arrive at a thorough understanding of the dynamics correlated to the phenomenology of consciousness in complex organisms. This is indicated by the fact that the molecular sciences either provide one or more mechanisms directly related to phenomenology or otherwise describe the dynamics of the underlying substrate. In addition, we (...) discuss substrate-independence in information-processing theories of consciousness and the issue of combination in panpsychist theories of consciousness, both from the angle of the molecular sciences. In any case, molecular details matter. (shrink)