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  1. Induced Pluripotent Stem Cell-Based Systems for Personalising Epilepsy Treatment: Research Ethics Challenges and New Insights for the Ethics of Personalised Medicine.Mary Jean Walker, Jane Nielsen, Eliza Goddard, Alex Harris & Katrina Hutchison - 2022 - American Journal of Bioethics Neuroscience 13 (2):120-131.
    This paper examines potential ethical and legal issues arising during the research, develop- ment and clinical use of a proposed strategy in personalized medicine (PM): using human induced pluripotent stem cell (iPSC)-derived tissue cultures as predictive models of individ- ual patients to inform treatment decisions. We focus on epilepsy treatment as a likely early application of this strategy, for which early-stage stage research is underway. In relation to the research process, we examine issues associated with biological samples; data; health; vulnerable (...)
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  • Individual differences, uniqueness, and individuality in behavioural ecology.Rose Trappes - 2022 - Studies in History and Philosophy of Science Part A 96 (C):18-26.
    In this paper I develop a concept of behavioural ecological individuality. Using findings from a case study which employed qualitative methods, I argue that individuality in behavioural ecology should be defined as phenotypic and ecological uniqueness, a concept that is operationalised in terms of individual differences such as animal personality and individual specialisation. This account make sense of how the term “individuality” is used in relation to intrapopulation variation in behavioural ecology. The concept of behavioural ecological individuality can sometimes be (...)
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  • What’s Going to Happen to Me? Prognosis in the Face of Uncertainty.Daniele Chiffi & Mattia Andreoletti - 2019 - Topoi 40 (2):319-326.
    Reasoning in medicine requires the critical use of a clinical methodology whose validity must be evaluated as well as its limits. In the last decade, an increasing amount of evidence has shown severe limitations and flaws in the conduct of prognostic studies. The main reason behind this fact is that prognostic judgments are at high risk of error. In this paper we investigate the pragmatic and illocutionary aspects of different forms of linguistic acts and judgments involved in clinical practice. More (...)
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  • Artificial Intelligence and Patient-Centered Decision-Making.Jens Christian Bjerring & Jacob Busch - 2020 - Philosophy and Technology 34 (2):349-371.
    Advanced AI systems are rapidly making their way into medical research and practice, and, arguably, it is only a matter of time before they will surpass human practitioners in terms of accuracy, reliability, and knowledge. If this is true, practitioners will have a prima facie epistemic and professional obligation to align their medical verdicts with those of advanced AI systems. However, in light of their complexity, these AI systems will often function as black boxes: the details of their contents, calculations, (...)
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