in this paper i assess Pierre Duhem’s criticism of crucial experiments, and argue that we have reasons to vindicate their existence. i then analize the experiments carried out by Fizeau and Foucault in 1850, and criticize Duhem’s interpretation of their results. i contend that the results of crucial experiences can be described in terms that are neutral with respect to the competing theories. For that reason an experimental result is relatively stable and open to different interpretations in the light of (...) new theories. i conclude by distinguishing successful crucial experiments from decisive experiments. The former are meant to provide evidence that confirms one theory and disconfirms its rivals, but not necessarily to provide sufficient reasons for accepting or rejecting one of those theories. (shrink)

We initially characterize what we’ll call existence problems as problems where there is evidence that a putative entity exists and this evidence is not easily dismissed; however, the evidence is not adequate to justify the claim that the entity exists, and in particular the entity hasn’t been detected. The putative entity is elusive. We then offer a strategy for determining whether an existence problem is philosophical or scientific. According to this strategy (1) existence problems are characterized in terms of causal (...) roles, and (2) these problems are categorized as scientific or philosophical on the basis of the epistemic context of putative realizers. We argue that the first step of the strategy is necessary to avoid begging the question with regard to categorization of existence problems, and the second step categorizes existence problems on the basis of a distinction between two ways in which an entity can be elusive. This distinction between kinds of elusiveness takes as background a standard account of inference to the best explanation. Applying this strategy, we argue that the existence of a multiverse is a scientific problem. (shrink)

A survey of models in immunology is conducted and distinct kinds of models are characterized based on whether models are material or conceptual, the distinctiveness of their epistemic purpose, and the criteria for evaluating the goodness of a model relative to its intended purpose. I argue that the diversity of models in interdisciplinary fields such as immunology reflects the fact that information about the phenomena of interest is gathered from different sources using multiple methods of investigation. To each model is (...) attached a description specifying how information about a phenomenon of interest has been acquired, highlighting points of commonality and difference between the methodological and epistemic histories of the information encapsulated in different models. These points of commonality and difference allow investigators to integrate findings from different models into more comprehensive explanatory accounts, as well as to troubleshoot anomalies and faulty accounts by going back to the original building blocks. (shrink)

This article discusses how inference to the best explanation can be justified as a practical meta - argument. It is, firstly, justified as a practical argument insofar as accepting the best explanation as true can be shown to further a specific aim. And because this aim is a discursive one which proponents can rationally pursue in — and relative to — a complex controversy, namely maximising the robustness of one’s position, IBE can be conceived, secondly, as a meta - argument. (...) My analysis thus bears a certain analogy to Sellars ’ well - known justification of inductive reasoning ; it is based on recently developed theories of complex argumentation. (shrink)

Although Duhem’s thesis that in physics crucial experiments are impossible contains some grains of truth in it, its effects have been greatly exaggerated. In this talk I argue against this and other associated theses by pointing out the various ways in which these theses can be curtailed. In the process of doing so, I examine a few recent attempts to overcome the problems posed by these theses and identify their strengths and weaknesses.

The high point of the falsification of physical theories in a standard view of the philosophy of science is the so-called crucial experiment. This experiment is a kind of manipulated empirical test, which provides the criterion for distinguishing between two rival hypotheses, where one is an acceptable theory due to passing the test, and the other turns out to be an unacceptable theory as it does not pass the test. The crucial experiment was supposed to play a significant role because, (...) in virtue of an empirical disconfirmation of one theory, the experiment was assumed to confirm the other as true. However, in 1906, in La théorie physique, son object et la structure (hereafter quoted in English translation as The Aim and Structure of Physical Theory (1906/1954)), Pierre Duhem famously argued against this view and stated that crucial experiments in physics are impossible as they are necessarily ambiguous and logically incomplete. His contention rested on the claim that, “[a] physical theory is not an explanation [of true reality in itself in virtue of some broad metaphysical ramification of physics]. It is a system of mathematical propositions, deduced from a small number of principles, which aim to represent as simply, as completely, and as accurately as possible a set of experimental laws” (ibid., p. 19). Furthermore, different theories could be equally suitable to represent a given group of experimental laws. And, assuming holism, no hypothesis could be tested in isolation, but merely as a part of a set of an entire scientific theory. The problem which Duhem identified in 1906 was slightly overshadowed and neglected in mainstream philosophy of science until the appearance of a challenging paper by Willard Van Orman Quine published in 1951 and entitled “Two Dogmas of Empiricism”. Quine’s paper caused a revival of interest in Duhem’s original formulation and gave a new impulse towards the problem in the form of the so-called Duhem-Quine thesis. The aim of this paper is to reconsider whether Duhem was right to argue that there are no crucial experiments in physics. In order to assess the validity of the thesis, first, this paper makes an exposition of Duhem’s arguments in their favour, and analyses the major criticisms of this position offered in the subject-literature of Adolf Grünbaum, who explicitly attacked the arguments for the thesis as inconclusive and false. Then, this paper presents possible modes of defence of the Duhem-Quine thesis and argues that the original formulation of the thesis is well qualified and plausible. Finally, this paper offers a pragmatic interpretation of the theory choice. (shrink)

Falsification no longer is the cornerstone of philosophy of science; but it still looms widely that scientists ought to drop an explanatory hypothesis in view of negative results. We shall argue that, to the contrary, negative empirical results are unable to disqualify causally explanatory hypotheses—not because of the shielding effect of auxiliary assumptions but because of the fact that the causal irrelevance of a factor cannot empirically be established. This perspective is elaborated at a case study taken from the history (...) of plant physiology: the formaldehyde model of photosynthesis, which for about sixty years dominated the field—despite the fact that in these sixty years all the attempts to conclusively demonstrate even the presence of formaldehyde in plants failed. (shrink)

: Our paper discusses the epistemic attitudes of particle physicists on the discovery of the Higgs boson at the Large Hadron Collider. It is based on questionnaires and interviews made shortly before and shortly after the discovery in 2012. We show, to begin with, that the discovery of a Standard Model Higgs boson was less expected than is sometimes assumed. Once the new particle was shown to have properties consistent with SM expectations – albeit with significant experimental uncertainties –, there (...) was a broad agreement that ‘a’ Higgs boson had been found. Physicists adopted a two-pronged strategy. On the one hand, they treated the particle as a SM Higgs boson and tried to establish its properties with higher precision; on the other hand, they searched for any hints of physics beyond the SM. This motivates our first philosophical thesis: the Higgs discovery, being of fundamental importance and establishing a new kind of particle, represented a crucial experiment if one interprets this notion in an appropriate sense. By embedding the LHC into the tradition of previous precision experiments and the experimental strategies thus established, underdetermination and confirmational holism are kept at bay. Second, our case study suggests that criteria of theory preference should be understood as epistemic and pragmatic values that have to be weighed in factual research practice. The Higgs discovery led to a shift from pragmatic to epistemic values as regards the mechanisms of electroweak symmetry breaking. Complex criteria, such as naturalness, combine epistemic and pragmatic different values, but are coherently applied by the community. (shrink)

Causal pluralism can be defended not only in respect to causal concepts and methodological guidelines, but also at the finer-grained level of causal inference from a particular source of evidence for causation. An argument for this last variety of pluralism is made based on an analysis of causal inference from randomized experiments (RCTs). Here, the causal interpretation of a statistically significant association can be established via multiple paths of reasoning, each relying on different assumptions and providing distinct elements of information (...) in favour of a causal interpretation. (shrink)

ABSTRACT There is a new argument form within theoretical biology. This form takes as input competing explanatory models; it yields as output the conclusion that one of these models is more plausible than the others. The driving force for this argument form is an analysis showing that one model exhibits more parametric robustness than its competitors. This article examines these inferences to the more robust explanation, analysing them as variants of inference to the best explanation. The article defines parametric robustness (...) and distinguishes it from more familiar kinds of robustness. The article also argues that parametric robustness is an explanatory virtue not subsumed by more familiar explanatory virtues, and that the plausibility verdicts in the conclusions of inferences to the more robust explanations are best interpreted as guidance for research activity, rather than claims about likely truth. 1Introducing Inference to the More Robust Explanation 2Inference to the More Robust Explanation in the Study of Apoptosis 2.1Regulating apoptosis 2.2Competing models and evidential indecision 2.3Measuring robustness 2.4Robustness as a guide to plausibility 2.5Varieties of robustness 3Inference to the More Robust Explanation as Inference to the Best Explanation 3.1The structure of inference to the best explanation 3.2Parametric robustness as an explanatory virtue rather than an explanandum 3.3Relation of parametric robustness to other explanatory virtues 4Epistemological Significance of Inference to the More Robust Explanation 4.1Plausibility in practice 4.2Plausibility in principle 5Conclusion. (shrink)

According to the hypothesis-generator account, valid extrapolations from a source to a target system are circular, since they rely on knowledge of relevant similarities and differences that can onl...

When the results of an experiment appears to disconfirm a hypothesis, how does one know whether it’s the hypothesis, or rather some auxiliary hypothesis or assumption, that is at fault? Philosophers’ answers to this question, now known as “Duhem’s problem,” have differed widely. Despite these differences, we affirm Duhem’s original position that the logical structure of this problem alone does not allow a solution. A survey of philosophical approaches to Duhem’s problem indicates that what allows any philosopher, or scientists for (...) that matter, to solve this problem is the addition of epistemic information that guides their assignment of praise and blame after a negative test. We therefore advocate a distinction between the logical and epistemic formulations of Duhem’s problem, the latter relying upon additional relevant information about the system being tested. Recognition of the role of this additional information suggests that some proposed solutions to the epistemic form of Duhem’s problem are preferable over others. (shrink)

Scientific hypotheses may either predict particular unknown facts or accommodate previously-known data. Although affirmed predictions are intuitively more rewarding than accommodations of established facts, opinions divide whether predictive hypotheses are also epistemically superior to accommodation hypotheses. This paper examines the contribution of predictive hypotheses to discoveries of several bio-molecular systems. Having all the necessary elements of the system known beforehand, an abstract predictive hypothesis of semiconservative mode of DNA replication was successfully affirmed. However, in defining the genetic code whose biochemical (...) basis was unclear, hypotheses were only partially effective and supplementary experimentation was required for its conclusive definition. Markedly, hypotheses were entirely inept in predicting workings of complex systems that included unknown elements. Thus, hypotheses did not predict the existence and function of mRNA, the multiple unidentified components of the protein biosynthesis machinery, or the manifold unknown constituents of the ubiquitin–proteasome system of protein breakdown. Consequently, because of their inability to envision unknown entities, predictive hypotheses did not contribute to the elucidation of cation theories remained the sole instrument to explain complex bio-molecular systems, the philosophical question of alleged advantage of predictive over accommodative hypotheses became inconsequential. (shrink)

The article analyses in detail the Meselson–Stahl experiment, identifying two novel difficulties for the crucial experiment account, namely, the fragility of the experimental results and the fact that the hypotheses under scrutiny were not mutually exclusive. The crucial experiment account is rejected in favour of an experimental-mechanistic account of the historical significance of the experiment, emphasizing that the experiment generated data about the biochemistry of DNA replication that is independent of the testing of the semi-conservative, conservative, and dispersive hypotheses. _1_ (...) Introduction _2_ The Meselson–Stahl Experiment _3_ Some Difficulties for the Crucial Experiment Account _3.1_ Additional experiments were required _3.2_ Simplicity considerations are unconvincing _3.3_ The fragility of the experimental results _3.4_ The problematic interpretation of falsifyng results _3.5_ Not all possible hypotheses considered or tested _3.6_ The tested hypotheses were not mutually exclusive _4_ The Historical and Scientific Significance of the Meselson–Stahl Experiment _4.1_ The challenge for the crucial experiment account _4.2_ A mechanistic perspective on the experiment _4.3_ The experimental design and its independence from theoretical speculations _4.4_ The advantages of a ‘bottom-up’ mechanistic account _5_ Conclusion. (shrink)