Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the ‘synaptic efficacy hypothesis’ as a paradigmatic explanation in neuroscience. Craver’s mosaic view has been influential in understanding synaptic efficacy by presenting long-term potentiation as a multi-level mechanism nested within a multi-level structure. This paper argues that the mosaic view fails to fully capture the explanatory power of the synaptic efficacy hypothesis due to assumptions about multi-level mechanisms. I present an alternative (...) approach that emphasizes the explanatory function of unification, accounting for the widespread consensus in neuroscience regarding synaptic efficacy by highlighting the stability of synaptic causal variables across different multi-level mechanisms. (shrink)

The periodic table is one of the best-known systems of classification in science. Because of the information it contains, it raises explanation-seeking questions. Quantum mechanical models of the behaviour of electrons may be seen as providing explanations in response to these questions. In this paper we first address the question ‘Do quantum mechanical models of atoms provide legitimate explanations?’ Because our answer is positive, our next question is ‘Are the explanations provided by quantum mechanical models of atoms mechanistic explanations?’. This (...) question is motivated by the fact that in many scientific disciplines, mechanistic explanations are abundant. Because our answer to the second question is negative, our last question is ‘What kind of explanation do quantum mechanical models of atom provide?’ By addressing these questions, we shed light on the nature of an important type of chemical explanation. (shrink)

“Explanation” refers to a wide range of activities, with a family resemblance between them. Most satisfactory explanations in a discipline for a domain fail to satisfy some general desiderata, while fulfilling others. This can happen in various ways. Why? An idealizing response would be to say that in real science explanations fall short along some dimensions, so that for any explanatory failure there is a conceivable improvement that addresses its shortcomings. The improvement may be more accurate causally or possess more (...) unifying power, or deliver deeper understanding. We formulate a drastically less idealizing response. We argue that there are typically trade-offs in explanation, so that in strengthening one explanatory virtue one will usually weaken another. Scientific explanations, if this is correct, are constrained by such trade-offs. Particular trade-offs are appropriate for particular explanatory vehicles. There are the overarching equations of theoretical physics, which produce unification at the expense of causal detail; there are theoretical models of phenomena that occupy a middle ground between generality and the detailed workings of particular cases and get closer to explaining the workings of specific systems at the expense of unification. Sometimes experiments aim at general causal patterns at the expense of particular detail; and sometimes they are designed to give us information of particular detail at the expense of generality. There are further trade-offs associated with other vehicles of explanation. We provide examples from physics and biology. (shrink)

This dissertation starts with a concise overview of what philosophers of science have written about unification and its role in scientific explanation during the last 50 years to provide the reader with some background knowledge. In order to bring unification back into the picture, I have followed two strategies, resulting respectively in Parts I and II of this dissertation. In Part I the idea of unification is used to refine and enrich the dominant causalmechanist and causal-interventionist accounts of scientific explanation. (...) In this part of the dissertation I bracket the classical ideas about unification: deduction and derivation. I do grant, for the sake of argument, that explanations are causal and argue that unification is important from within this causalist perspective. In Part II I continue my strategy of digging into scientific practice to find cases of ontological unification. But here I distance myself from the dominant literature that all explanations must be causal. I will investigate whether explanatory unification is possible in non-causal explanations. Part III contains some further reflections and conclusions. I will formulate my primary results, and I will elaborate on their implications for thinking about unification and explanation. The different forms of ontological unification were quite diverse. This relates to the method I have used. Throughout this dissertation the types of unification that were discussed emerged from digging into scientific practice. This philosophy-of-science-practice approach steered me towards a pluralistic view on unification and on explanation. In this dissertation I do not try to develop a new model of explanation and compare it to existing models. The aim is to show that there are important types of explanatory practice which cannot be properly analyzed if we neglect unification as a desideratum for explanations. (shrink)