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  1. The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory.Ana M. Soto & Carlos Sonnenschein - 2011 - Bioessays 33 (5):332-340.
    The somatic mutation theory (SMT) of cancer has been and remains the prevalent theory attempting to explain how neoplasms arise and progress. This theory proposes that cancer is a clonal, cell‐based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms. The SMT has not been rigorously tested, and several lines of evidence raise questions that are not addressed by this theory. Herein, we propose experimental strategies that may validate the SMT. We also call attention (...)
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