Aristotle’s On generation and corruption raises a vital question: how is mixture, or what we would now call chemical combination, possible? It also offers an outline of a solution to the problem and a set of criteria that a successful solution must meet. Understanding Aristotle’s solution and developing a viable peripatetic theory of chemical combination has been a source of controversy over the last two millennia. We describe seven criteria a peripatetic theory of mixture must satisfy: uniformity, recoverability, potentiality, equilibrium, (...) alteration, incompleteness, and the ability to distinguish mixture from generation, corruption, juxtaposition, augmentation, and alteration. After surveying the theories of Philoponus , Avicenna , Averroes , and John M. Cooper , we argue for the merits of Richard Rufus of Cornwall’s theory. Rufus was a little known scholastic philosopher who became a Franciscan theologian in 1238, after teaching Aristotelian natural philosophy as a secular master in Paris. Lecturing on Aristotle’s De generatione et corruptione, around the year 1235, he offered his students a solution to the problem of mixture that we believe satisfies Aristotle’s seven criteria.Author Keywords: Mixture; Mixt; Chemical combination; Accidental potential; Potential; Elements; Medieval chemistry; Peripatetic chemistry; Aristotelian science; Richardus Rufus; Averroes ; Avicenna ; Philoponus ; John M. Cooper. (shrink)