In this paper I shall examine the interrelationships holding between four of the main theses of Quine's philosophy. (1)Ho1ism (2)Underdetennination of scientific theories (3) Indeterminacy of translation (4) Ontological Relativity -/- These four doctrines have generated a lasting controversy: in one interpretation they seem to be false and in the other they are threatened to collapse into triviality. Moreover it has been claimed that they cannot be consistently upheld together. I shall argue, on the contrary, that they are true, original (...) and mutually consistent. (shrink)