Recent successes of systems biology clarified that biological functionality is multilevel. We point out that this fact makes it necessary to revise popular views about macromolecular functions and distinguish between local, physico-chemical and global, biological functions. Our analysis shows that physico-chemical functions are merely tools of biological functionality. This result sheds new light on the origin of cellular life, indicating that in evolutionary history, assignment of biological functions to cellular ingredients plays a crucial role. In this wider picture, even if (...) aggregation of chance mutations of replicator molecules and spontaneously self-assembled proteins led to the formation of a system identical with a living cell in all physical respects but devoid of biological functions, it would remain an inanimate physical system, a pseudo-cell or a zombie-cell but not a viable cell. In the origin of life scenarios, a fundamental circularity arises, since if cells are the minimal units of life, it is apparent that assignments of cellular functions require the presence of cells and vice versa. Resolution of this dilemma requires distinguishing between physico-chemical and biological symbols as well as between physico-chemical and biological information. Our analysis of the concepts of symbol, rule and code suggests that they all rely implicitly on biological laws or principles. We show that the problem is how to establish physico-chemically arbitrary rules assigning biological functions without the presence of living organisms. We propose a solution to that problem with the help of a generalized action principle and biological harnessing of quantum uncertainties. By our proposal, biology is an autonomous science having its own fundamental principle. The biological principle ought not to be regarded as an emergent phenomenon. It can guide chemical evolution towards the biological one, progressively assigning greater complexity and functionality to macromolecules and systems of macromolecules at all levels of organization. This solution explains some perplexing facts and posits a new context for thinking about the problems of the origin of life and mind. (shrink)

Although biological autonomy is widely discussed, its description in scientific terms remains elusive. I present here a series of recent evidences on the existence of genuine biological autonomy. Nevertheless, nowadays it seems that the only acceptable ground to account for any natural phenomena, including biological autonomy, is physics. But if this were the case, then arguably there would be no way to account for genuine biological autonomy. The way out of such a situation is to build up an exact theoretical (...) biology, and one of the first steps is to clarify the basic concepts of biology, among them biological aim, function and autonomy. We found a physical mechanism to realize biological autonomy, namely, biologically initiated vacuum processes. In the newly emerging picture, biological autonomy shows up as a new, fundamental and inevitable element in our scientific world picture. It offers new perspectives for solving problems regarding the origin and nature of life, connecting ancient Greek philosophy with modern science. Namely, our proposal sheds light in what sense can the God as conceived by Xenophanes can move the material objects of the Universe by its thoughts without toil. (shrink)

This book argues for the need to put into practice a profound and comprehensive intellectual revolution, affecting to a greater or lesser extent all branches of scientific and technological research, scholarship and education. This intellectual revolution differs, however, from the now familiar kind of scientific revolution described by Kuhn. It does not primarily involve a radical change in what we take to be knowledge about some aspect of the world, a change of paradigm. Rather it involves a radical change in (...) the fundamental, overall intellectual aims and methods of inquiry. At present inquiry is devoted to the enhancement of knowledge. This needs to be transformed into a kind of rational inquiry having as its basic aim to enhance personal and social wisdom. This new kind of inquiry gives intellectual priority to the personal and social problems we encounter in our lives as we strive to realize what is desirable and of value – problems of knowledge and technology being intellectually subordinate and secondary. For this new kind of inquiry, it is what we do and what we are that ultimately matters: our knowledge is but an aspect of our life and being. (shrink)

Many scientists and philosophers of science think that beauty should play a role in theory selection. Physicists like Paul Dirac and Steven Weinberg explicitly claim that the ultimate explanations of the physical world must be beautiful. And philosophers of science like Peter Lipton say that we should expect the loveliest theory to also be the most likely. In this paper, I contend that these arguments from loveliness bear a striking similarity to Thomas Aquinas’ arguments from fittingness; both seem to presume (...) that the most beautiful theory is also the most probable. To do this, I first explain the explanatory virtues that are commonly thought to be constitutive of a lovely theory. Second, I elucidate Aquinas’ arguments from fittingness and show how they work in light of his account of beauty. Lastly, I connect the two kinds of aesthetic arguments and show the extent to which they overlap. (shrink)

Scientists often use aesthetic values in the evaluation and choice of theories. Aesthetic values are not only regarded as leading to practically more useful theories but are often taken to stand in a special epistemic relation to the truth of a theory such that the aesthetic merit of a theory is evidence of its truth. This paper explores what aesthetic considerations influence scientists' reasoning, how such aesthetic values relate to the utility of a scientific theory, and how one can justify (...) the epistemic role for such values. The paper examines ways in which the link between beauty and truth can be defended, the challenges facing such accounts, and explores alternative epistemic roles for aesthetic values in scientific practice. (shrink)

Although chemical phenomena are primarily associated with electrons in atoms, ions, and molecules, the masses, charges, spins, and other properties of the nuclei in these species contribute significantly as well. Isotopes, for instance, have proven invaluable in chemistry, in particular the elucidation of reaction mechanisms. Elements with unstable nuclei, for example carbon-14 undergoing beta decay, have enriched chemistry and many other scientific disciplines. The nuclei of all elements have a much more subtle and largely unknown effect on chemical phenomena. All (...) nuclei are innately chiral and, because electrons can penetrate nuclei, all atoms and molecules are likewise chiral. This article describes in considerable detail the discovery of chiral nuclei, how this unusual chirality may influence the chemical behavior of atoms and molecules, and how atomic chirality may have been responsible for the synthesis of optically active molecules in the pre-biotic world. (shrink)

For the basic areas of physics‐classical mechanics, classical field theories, and quantum mechanics‐there are local dynamical theories that offer complete descriptions of systems when the proper subsidiary conditions also are provided. For all these cases there are global theories from which the local theories can be derived. Symmetries and their relation to conservation laws are reviewed. The standard model of elementary particles is mentioned, along with frontier questions about them. A case against reductionism in physics is presented.

The general attributes of ecosystems are examined and a naturally occurring reference ecosystem is established, comparable with the isolated system of classical thermodynamics. Such an autonomous system with a stable, periodic input of energy is shown to assume certain structural characteristics that have an identifiable thermodynamic basis. Individual species tend to assume a state of least dissipation; this is most clearly evident in the dominant species (the species with the best integration of energy acquisition and conservation). It is concluded that (...) ecosystem structure results from the antagonistic interaction of two nearly equal forces. These forces have their origin in the Principle of Most Action (least dissipation or least entropy production) and the universal Principle of Least Action. Most action is contingent on the equipartitioning of the energy available, through uniform interaction of similar individuals. The trend to Least action is contingent on increased dissipation attained through increasing diversity and increasing complexity. These principles exhibit a basic asymmetry. Given the operation of these opposing principles over evolutionary time, it is argued that ecosystems originated in the vicinity of thermodynamic equilibrium through the resonant amplification of reversible fluctuations. On account of the basic asymmetry the system was able to evolve away from thermodynamic equilibrium provided that it remained within the vicinity of ergodynamic equilibrium (equilibrium maintained by internal work, where the opposing forces are equal and opposite).At the highest level of generalization there appear to be three principles operating: i) maximum association of free-energy and materials; ii) energy conservation (deceleration of the energy flow) through symmetric interaction and increased homogeneity; and iii) the principle of least action which induces acceleration of the energy flow through asymmetrical interaction. The opposition and asymmetry of the two forces give rise to natural selection and evolution. (shrink)

Physicists often appeal to the beauty of a theory as a way to judge its credibility, and the most prevalent component of this beauty is symmetry. This paper describes the role and structure of symmetry arguments in physics. It demonstrates that the epistemic authority of an appeal to symmetry is based on empirical evidence and is independent of any aesthetic judgment. Furthermore, symmetry in nature is not evidence of design. Just the opposite, symmetry indicates a lack of planning. It is (...) about nature's disregard for details. (shrink)

A rationalist and realist model of scientific revolutions will be constructed by reference to two categories of criteria of theory-evaluation, denominated indicators of truth and of beauty. Whereas indicators of truth are formulateda priori and thus unite science in the pursuit of verisimilitude, aesthetic criteria are inductive constructs which lag behind the progression of theories in truthlikeness. Revolutions occur when the evaluative divergence between the two categories of criteria proves too wide to be recomposed or overlooked. This model of revolutions (...) depends upon a substantial new treatment of aesthetic criteria in science with which much of the paper will therefore be occupied. (shrink)

We propose to replace the present, 400 years-old scientific world picture with an updated, essentially complete model describing the architecture of the Universe. We show that three levels of reality, namely: phenomena, laws and first principles, together form the Universe. Moreover, on the basis of observable behaviour, phenomena, laws and principles can be classified into three fundamentally different branches of natural sciences: physical, biological and psychological. It is shown that the first principles have an ultimate role in the Universe, concentrating (...) the governing potential of the Universe in a most elegant, comprehensive and fundamental manner. We define life and introduce the first principle of biology, i.e. the Bauer principle and show that it is the most fundamental of all the three first principles of the Universe. We consider the similarities and differences of our biological principle in comparison to the onto-poietic principle of Anna-Teresa Tymieniecka. With the help of the three first principles of natural sciences, we present arguments indicating the ultimate basis of the long awaited universal science that has a determining role for the development and perspectives of sciences, philosophy, religion, art, and the future of civilization. (shrink)