In this paper, I want to compere some of the ideas of Martin Buber, a distinguished existential philosopher, with Muhammad Husain Tabatabaei, one of the significant figures of contemporary philosophy and Sufism in Shia Islam. In the first section, I shall briefly introduce these two important philosophers and in the second part, I will consider the relationship between God and the creatures form their point of view. In this section I will show that there is a similarity between Buber’s conception of “I-Thou” with Tabatabaei’s view on “I” as the only way toward reality. In section three, I will compare their perspectives towards good and evil. In the fourth section, I will explain Tabatabaei’s novel argument for an eternal reality and I will show that how it is similar to Buber’s Eternal Thou.