In an ever-changing world, when we search for answers on our present challenges, it can be tricky to extrapolate past realities when concerning science-based issues. Climate change, public health or artificial intelligence embody issues on how scientific evidence is often challenged, as false beliefs could drive the design of public policies and legislation. Therefore , how can we foresee if science can tip the scales of political legislation? In this article, we outline how models of historical cases can be used to predict and understand how scientific evidence can influence the emergence (or fall-back) of science based-legislation. We also present frameworks on how to use past episodes of History of Science and Alternative History insights to build epistemic models, based on previous successful approaches on the spread of scientific misinformation. These models will help the accuracy of the design of eventual alternative realities, that can come insightful on present decision making methodologies.