We present a theoretical view of the cellular foundations for network-level processes involved in producing our conscious experience.
Inputs to apical synapses in layer 1 of a large subset of neocortical cells are summed at an integration zone near the top of their
apical trunk. These inputs come from diverse sources and provide a context within which the transmission of information abstracted
from sensory input to their basal and perisomatic synapses can be amplified when relevant. We argue that apical amplification enables
conscious perceptual experience and makes it more flexible, and thus more adaptive, by being sensitive to context. Apical amplification
provides a possible mechanism for recurrent processing theory that avoids strong loops. It makes the broadcasting hypothesized by
global neuronal workspace theories feasible while preserving the distinct contributions of the individual cells receiving the broadcast.
It also provides mechanisms that contribute to the holistic aspects of integrated information theory. As apical amplification is highly
dependent on cholinergic, aminergic, and other neuromodulators, it relates the specific contents of conscious experience to global
mental states and to fluctuations in arousal when awake. We conclude that apical dendrites provide a cellular mechanism for the
context-sensitive selective amplification that is a cardinal prerequisite of conscious perception.