The Ethics of Placebo-controlled Trials: Methodological Justifications

Contemporary Clinical Trials 36 (2):510-14 (2013)
Download Edit this record How to cite View on PhilPapers
The use of placebo controls in clinical trials remains controversial. Ethical analysis and international ethical guidance permit the use of placebo controls in randomized trials when scientifically indicated in four cases: (1) when there is no proven effective treatment for the condition under study; (2) when withholding treatment poses negligible risks to participants; (3) when there are compelling methodological reasons for using placebo, and withholding treatment does not pose a risk of serious harm to participants; and, more controversially, (4) when there are compelling methodological reasons for using placebo, and the research is intended to develop interventions that can be implemented in the population from which trial participants are drawn, and the trial does not require participants to forgo treatment they would otherwise receive. The concept of methodological reasons is essential to assessing the ethics of placebo controls in these controversial last two cases. This article sets out key considerations relevant to considering whether methodological reasons for a placebo control are compelling.
(categorize this paper)
PhilPapers/Archive ID
Upload history
Archival date: 2016-08-25
View other versions
Added to PP index

Total views
290 ( #20,052 of 2,427,843 )

Recent downloads (6 months)
57 ( #13,048 of 2,427,843 )

How can I increase my downloads?

Downloads since first upload
This graph includes both downloads from PhilArchive and clicks on external links on PhilPapers.