Epistemological objections to moral realism allege that realism entails moral skepticism. Many philosophers have assumed that theistic moral realists can easily avoid such objections. In this article, I argue that things are not so easy: theists run the risk of violating an important constraint on replies to epistemological objections, according to which replies to such objections may not rely on substantive moral claims of a certain kind. Yet after presenting this challenge, I then argue that theists can meet it, successfully replying to the objections without relying on the problematic kinds of substantive moral claims. Theists have a distinctive and plausible reply to epistemological objections to moral realism.