Abstract

Deep learning, a transformative force in computational biology, has reshaped biological data analysis and interpretation terrain. This review delves into the multifaceted role of deep knowledge in this field, exploring its historical roots, inherent advantages, and persistent challenges. It investigates explicitly its application in two pivotal domains: DNA sequence classification, where it has been used to identify disease-causing mutations, and protein structure prediction from sequence data, where it has enabled the accurate determination of protein tertiary structures. Moreover, it offers a glimpse into the future trajectory of this dynamic field, sparking intrigue and excitement about the potential of deep learning. Deep learning, a powerful tool in computational biology, can be traced back to the inception of 'threshold logic,' a fusion of algorithmic principles and mathematical frameworks devised to mimic cognitive processes. This seminal breakthrough, which introduced the concept of a threshold function that could be used to model complex decision-making processes, paved the way for deep learning to decipher intricate patterns embedded within vast biological datasets. Deep learning presents many benefits, including precise disease diagnosis, novel drug discovery, and personalized medicine facilitation. Its prowess lies in handling vast, intricate datasets while enhancing generalization capabilities, a testament to its evolution and development that we can appreciate.