Genotype–phenotype mapping and the end of the ‘genes as blueprint’ metaphor

Download Edit this record How to cite View on PhilPapers
Abstract
In a now classic paper published in 1991, Alberch introduced the concept of genotype–phenotype (G!P) mapping to provide a framework for a more sophisticated discussion of the integration between genetics and developmental biology that was then available. The advent of evo-devo first and of the genomic era later would seem to have superseded talk of transitions in phenotypic space and the like, central to Alberch’s approach. On the contrary, this paper shows that recent empirical and theoretical advances have only sharpened the need for a different conceptual treat- ment of how phenotypes are produced. Old-fashioned metaphors like genetic blueprint and genetic programme are not only woefully inadequate but positively misleading about the nature of G!P, and are being replaced by an algorithmic approach emerging from the study of a variety of actual G!P maps. These include RNA folding, protein function and the study of evolvable soft- ware. Some generalities are emerging from these disparate fields of analysis, and I suggest that the concept of ‘developmental encoding’ (as opposed to the classical one of genetic encoding) provides a promising computational–theoretical underpinning to coherently integrate ideas on evolvability, modularity and robustness and foster a fruitful framing of the G!P mapping problem.
PhilPapers/Archive ID
PIGGMA
Revision history
Archival date: 2015-11-21
View upload history
References found in this work BETA

No references found.

Add more references

Citations of this work BETA
What Are We to Make of the Concept of Race? Thoughts of a Philosopher–Scientist.Massimo Pigliucci - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):272-277.
More on How and Why: Cause and Effect in Biology Revisited.Laland, Kevin N.; Odling-Smee, John; Hoppitt, William & Uller, Tobias
Explanatory Integration Challenges in Evolutionary Systems Biology.Green, Sara; Fagan, Melinda & Jaeger, Johannes

View all 14 citations / Add more citations

Added to PP index
2011-03-21

Total views
476 ( #6,893 of 44,235 )

Recent downloads (6 months)
25 ( #26,285 of 44,235 )

How can I increase my downloads?

Downloads since first upload
This graph includes both downloads from PhilArchive and clicks to external links.