Mechanism of development of pre-eclampsia linking breathing disorders to endothelial dysfunction

Medical Hypotheses 73:163-166 (2009)
Download Edit this record How to cite View on PhilPapers
Abstract
High blood pressure is an important component of pre-eclampsia. The underlying mechanism of development of hypertension in pre-eclampsia is complicated and still remains obscure. Several theories have been advanced including endothelial dysfunction, uteroplacental insufficiency leading to generalized vasoconstriction, increased cardiac output, and sympathetic hyperactivity. Increased blood flow and pressure are thought to lead to capillary dilatation, which damages end-organ sites, leading to hypertension, proteinuria and edema. Additional theories have been put forward based on epidemiological research, implicating immunological and genetic factors. None of these theories have been substantiated. Based on a review of literature this paper postulates that the initiating event for the development of preeclampsia is intermittent hypoxia associated with irregular breathing during sleep, hypoapnea, apnea,inadequate respiratory excursions during the waking hours and inadequate cardiopulmonary synchronization (abnormal sympatho-vagal balance).
Keywords
No keywords specified (fix it)
Categories
(categorize this paper)
PhilPapers/Archive ID
RAVMOD
Revision history
Archival date: 2017-01-04
View upload history
References found in this work BETA

Add more references

Citations of this work BETA
Augmentation of Mind-Body Therapy and Role of Deep Slow Breathing.Jerath Ravinder & Vernon A. Barnes - 2009 - Journal of Complementary and Integrative Medicine 1:1-7.

Add more citations

Added to PP index
2017-01-04

Total views
87 ( #28,518 of 43,016 )

Recent downloads (6 months)
42 ( #16,376 of 43,016 )

How can I increase my downloads?

Downloads since first upload
This graph includes both downloads from PhilArchive and clicks to external links.