Gut feelings of safety: Tolerance to the microbiota mediated by innate immune receptors

Microbiology and Immunology 59 (10):573-585 (2015)
  Copy   BIBTEX

Abstract

To enable microbial colonisation of the gut mucosa, the intestinal immune system must not only react to danger signals but also recognize cues that indicate safety. Safety recognition, paradoxically, is mediated by the same environmental sensors that are involved in signalling danger. Indeed, in addition to their well established role in inducing inflammation in response to stress signals, pattern recognition receptors (PRRs) and a variety of metabolic sensors also promote gut-microbiota symbiosis by responding to "microbial symbiosis factors", "resolution-associated molecular patterns", markers of energy extraction and other signals indicating the absence of pathogenic infection and tissue damage. Here we focus on how the paradoxical role of immune receptors and other environmental sensors define the microbiota signature of the individual.

Author's Profile

Bartlomiej Swiatczak
Cambridge University

Analytics

Added to PP
2015-08-28

Downloads
211 (#63,395)

6 months
105 (#31,923)

Historical graph of downloads since first upload
This graph includes both downloads from PhilArchive and clicks on external links on PhilPapers.
How can I increase my downloads?