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  1. Evolution and RNA Relics. A Systems Biology View.Jacques Demongeot, Nicolas Glade & Andrés Moreira - 2008 - Acta Biotheoretica 56 (1-2):5-25.
    The genetic code has evolved from its initial non-degenerate wobble version until reaching its present state of degeneracy. By using the stereochemical hypothesis, we revisit the problem of codon assignations to the synonymy classes of amino-acids. We obtain these classes with a simple classifier based on physico-chemical properties of nucleic bases, like hydrophobicity and molecular weight. Then we propose simple RNA ring structures that present, overlap included, one and only one codon by synonymy class as solutions of a combinatory variational (...)
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  • Biological boundaries and biological age.Jacques Demongeot - 2009 - Acta Biotheoretica 57 (4):397-418.
    The chronologic age classically used in demography is often unable to give useful information about which exact stage in development or aging processes has reached an organism. Hence, we propose here to explain in some applications for what reason the chronologic age fails in explaining totally the observed state of an organism, which leads to propose a new notion, the biological age. This biological age is essentially determined by the number of divisions before the Hayflick’s limit the tissue or mitochondrion (...)
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  • Robustness in Regulatory Networks: A Multi-Disciplinary Approach.Jacques Demongeot, Adrien Elena & Sylvain Sené - 2008 - Acta Biotheoretica 56 (1-2):27-49.
    We give in this paper indications about the dynamical impact coming from the main sources of perturbation in biological regulatory networks. First, we define the boundary of the interaction graph expressing the regulations between the main elements of the network . Then, we search what changes in the state values on the boundary could cause some changes of states in the core of the system . After, we analyse the role of the mode of updating on the asymptotics of the (...)
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