Psychotropic and other drugs can alter brain mechanisms regulating the formation, storage, and retrieval of different types of memory. These include “off label” uses of existing drugs and new drugs designed specifically to target the neural bases of memory. This paper discusses the use of beta-adrenergic antagonists to prevent or erase non-conscious pathological emotional memories in the amygdala. It also discusses the use of novel psychopharmacological agents to enhance long term semantic and short term working memory by altering storage and (...) retrieval mechanisms in the hippocampus and prefrontal cortex. Although intervention in the brain to alter memory as therapy or enhancement holds considerable promise, the long term effects of experimental drugs on the brain and memory are not known. More studies are needed to adequately assess the potential benefits and risks of these interventions. (shrink)

Over 100 years ago, Frances Galton began the empirical study of autobiographical memory by devising a technique in which he explored the capacity for a cue word to elicit the recollection of events from earlier life (Galton, 1883). After a century of neglect, the topic began to re-emerge, stimulated by the work of Robinson (1976) using the technique on groups of normal subjects, by Crovitz’s work on its application to patients with memory deficits (Crovitz & Schiffman, 1974), and by the (...) detailed diary study of her own autobiographical memory carried out by Marigold Linton (Linton, 1975). This early wave of interest was focused by Rubin’s edited book on the topic (Rubin, 1986) which captured a broad and growing interest in autobiographical memory. This trend was reflected very strongly in the submissions to the second conference on Practical Aspects of Memory, in which the study of autobiographical memory represented one of the major strands (Gruneberg, Morris & Sykes, 1988), featuring prominently in both the opening and concluding addresses (Baddeley, 1988; Neisser, 1988). (shrink)