Borrowing from evolutionary biology, existentialism, developmental psychology, and social learning theory, an integrated model of human behavior is applied to several forms of self-destructive behavior, to include anorexia nervosa, suicide, substance abuse, and pathological gambling. It is argued that self-destructive behavior is a function of how the individual psychologically construes survival and copes with perceptions of isolation and separation from the environment. The paradox of self-destructive behavior in organisms motivated by self-preservation is resolved by taking note of the fact that (...) self-destruction stems from peopleís efforts to survive psychologically and resolve the subjectóobject duality, even when this places their physical well-being in jeopardy. (shrink)