American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

For the North American Nietzsche Society group meeting at the 2013 Eastern Division Meeting of the APA in Baltimore, the program committee invited Professor Jesse Prinz to deliver remarks on the contribution and the uniqueness of Nietzsche’s genealogical method. At the panel, chaired by R. Lanier Anderson on December 28, 2013, Rahul Chaudhri and Mark Migotti commented on his presentation, “Genealogies of Morals: Nietzsche’s Method Compared.” We are pleased to present Professor Prinz’s essay and both commentaries in this issue. Also (...) included here are the winning selections from the annual North American Nietzsche Society call for... (shrink)