In 1983, Dr. J. Robin Warren and Dr. Barry Marshall reported finding a new kind of bacteria in the stomachs of people with gastritis. Warren and Marshall were soon led to the hypothesis that peptic ulcers are generally caused, not by excess acidity or stress, but by a bacterial infection. Initially, this hypothesis was viewed as preposterous, and it is still somewhat controversial. In 1994, however, a U. S. National Institutes of Health Consensus Development Panel concluded that infection appears to (...) play an important contributory role in the pathogenesis of peptic ulcers, and recommended that antibiotics be used in their treatment. Peptic ulcers are common, affecting up to 10% of the population, and evidence has mounted that many ulcers can be cured by eradicating the bacteria responsible for them. (shrink)

This paper investigates the revolutionary conceptual changes that took place when the phlogiston theory of Stahl was replaced by the oxygen theory of Lavoisier. Using techniques drawn from artificial intelligence, it represents the crucial stages in Lavoisier's conceptual development from 1772 to 1789. It then sketches a computational theory of conceptual change to account for Lavoisier's discovery of the oxygen theory and for the replacement of the phlogiston theory.