The organism-in-its-environment is recognized as the basic unit of analysis when dealing with living beings. This paper seeks to define the fundamental implications of the concept of the organism-in-its-environment in terms of the biosemiotic concept of human distributed cognition. Human distributed cognition in a biosemiotic context is defined as the ability of a self-referencing organism-in-its-environment to interact with its environment to satisfy its physiological and social needs to survive and sustain itself. The ontogenetic development of the organism-in-its-environment serves as the (...) backdrop to discover the implications of distributed cognition that have general applicability in organisms, but in this paper, are made relevant to human beings. (shrink)