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Hedgehog signalling as an antagonist of ageing and its associated diseases

Monireh Dashti, Maikel P. Peppelenbosch & Farhad Rezaee

Bioessays 34 (10):849-856 (2012)

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Human senescence.Thomas B. L. Kirkwood - 1996 - Bioessays 18 (12):1009-1016.details Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of (...) the task that remains. (shrink) Download Export citation Bookmark 4 citations
Greased hedgehogs: New links between hedgehog signaling and cholesterol metabolism.Rainer Breitling - 2007 - Bioessays 29 (11):1085-1094.details The close link between signaling by the developmental regulators of the Hedgehog family and cholesterol biochemistry has been known for some time. The morphogen is covalently attached to cholesterol in a peculiar autocatalytic reaction and embryonal disruption of cholesterol synthesis leads to malformations that mimic Hh signaling defects. Recently, it was furthermore shown that secreted Hh could hitchhike on lipoprotein particles to establish its morphogenic gradient in the developing embryo. Additionally, there is new evidence that the Hh‐receptor Patched transmits the (...) Download Export citation Bookmark 2 citations
The free‐radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan.John R. Speakman & Colin Selman - 2011 - Bioessays 33 (4):255-259.details Recent work on a small European cave salamander (Proteus anguinus) has revealed that it has exceptional longevity, yet it appears to have unexceptional defences against oxidative damage. This paper comes at the end of a string of other studies that are calling into question the free‐radical damage theory of ageing. This theory rose to prominence in the 1990s as the dominant theory for why we age and die. Despite substantial correlative evidence to support it, studies in the last five years (...) Download Export citation Bookmark 4 citations
Ageing as a price of cooperation and complexity.Huba J. M. Kiss, Ágoston Mihalik, Tibor Nánási, Bálint Őry, Zoltán Spiró, Csaba Sőti & Peter Csermely - 2009 - Bioessays 31 (6):651-664.details The network concept is increasingly used for the description of complex systems. Here, we summarize key aspects of the evolvability and robustness of the hierarchical network set of macromolecules, cells, organisms and ecosystems. Listing the costs and benefits of cooperation as a necessary behaviour to build this network hierarchy, we outline the major hypothesis of the paper: the emergence of hierarchical complexity needs cooperation leading to the ageing (i.e. gradual deterioration) of the constituent networks. A stable environment develops cooperation leading (...) Download Export citation Bookmark 2 citations

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