This is a contribution to a book on quantum gravity and philosophy. I discuss nature and origin of the problem of quantum gravity. I examine the knowledge that may guide us in addressing this problem, and the reliability of such knowledge. In particular, I discuss the subtle modification of the notions of space and time engendered by general relativity, and how these might merge into quantum theory. I also present some reflections on methodological questions, and on some general issues in (...) philosophy of science which are are raised by, or a relevant for, the research on quantum gravity. (shrink)

Systems biology is largely tributary to genomics and other “omic” disciplines that generate vast amounts of structural data. “Omics”, however, lack a theoretical framework that would allow using these data sets as such (rather than just tiny bits that are extracted by advanced data-mining techniques) to build explanatory models that help understand physiological processes. Systems biology provides such a framework by adding a dynamic dimension to merely structural “omics”. It makes use of bottom-up and top-down models. The former are based (...) on data about systems components, the latter on systems-level data. We trace back both modeling strategies (which are often used to delineate two branches of the field) to the modeling of metabolic and signaling pathways in the bottom-up case, and to biological cybernetics and systems theory in the top-down case. We then argue that three roots of systems biology must be discerned to account adequately for the structure of the field: pathway modeling, biological cybernetics, and “omics”. We regard systems biology as merging modeling strategies (supplemented by new mathematical procedures) from data-poor fields with data supply from a field that is quite deficient in explanatory modeling. After characterizing the structure of the field, we address some epistemological and ontological issues regarding concepts on which the top-down approach relies and that seem to us to require clarification. This includes the consequences of identifying modules in large networks without relying on functional considerations, the question of the “holism” of systems biology, and the epistemic value of the “systeome” project that aspires to become the cutting edge of the field. (shrink)

Despite the impressive body of evidence supporting the existence of a mirror neuron (MN) system for action, the original claim regarding its crucial role in action understanding remains controversial. Emma Borg has recently launched a sharp attack on this claim, with the aim of demonstrating that neither the original version nor the subsequent revisions of the MN hypothesis tell us very much about how intentional attribution actually works. In this article I take up the challenge she issues in the title (...) of her paper (If Mirror Neurons are the Answer, What was the Question?) and argue that what MNs offer is not as Borg claims 'an extremely limited' picture of action understanding but rather an enriched picture that brings to light aspects of social cognition hitherto ignored in the mind-reading literature, showing how intentional motor components of action can shape social cognition prior to and apart from any forms of deliberate mentalizing. (shrink)

String theory currently is the only viable candidate for a unified description of all known natural forces. This article tries to demonstrate that the fundamental structural and methodological differences that set string theory apart from other physical theories have important philosophical consequences. Focussing on implications for the realism debate in philosophy of science, it is argued that both poles of that debate face new problems in the context of string theory. On the one hand, the claim of underdetermination of scientific (...) theory by the available empirical data, which is a pivotal element of empiricism, loses much of its plausibility. On the other hand, the dissolution of any meaningful notion of an external ontological object destroys the basis for conventional versions of scientific realism. String theory seems to suggest an intermediate position akin to Structural Realism that is based on a newly emerging principle, to be called the principle of theoretical uniqueness. (shrink)

I deny that the world is fundamentally causal, deriving the skepticism on non-Humean grounds from our enduring failures to find a contingent, universal principle of causality that holds true of our science. I explain the prevalence and fertility of causal notions in science by arguing that a causal character for many sciences can be recovered, when they are restricted to appropriately hospitable domains. There they conform to a loose collection of causal notions that form a folk science of causation. This (...) recovery of causation exploits the same generative power of reduction relations that allows us to recover gravity as a force from Einstein's general relativity and heat as a conserved fluid, the caloric, from modern thermal physics, when each theory is restricted to appropriate domains. Causes are real in science to the same degree as caloric and gravitational forces. (shrink)

Saunders has recently claimed that ``identical quantum particles'' with an anti-symmetric state (fermions) are weakly discernible objects, just like irreflexively related ordinary objects in situations with perfect symmetry (Black's spheres, for example). Weakly discernible objects have all their qualitative properties in common but nevertheless differ from each other by virtue of (a generalized version of) Leibniz's principle, since they stand in relations an entity cannot have to itself. This notion of weak discernibility has been criticized as question begging, but we (...) defend and accept it for classical cases likes Black's spheres. We argue, however, that the quantum mechanical case is different. Here the application of the notion of weak discernibility indeed is question begging and in conflict with standard interpretational ideas. We conclude that the introduction of the conceptual resource of weak discernibility does not change the interpretational status quo in quantum mechanics. (shrink)

Mirror neurons are neurons which fire in two distinct conditions: (i) when an agent performs a specific action, like a precision grasp of an object using fingers, and (ii) when an agent observes that action performed by another. Some theorists have suggested that the existence of such neurons may lend support to the simulation approach to mindreading (e.g. Gallese and Goldman, 1998, 'Mirror neurons and the simulation theory of mind reading'). In this note I critically examine this suggestion, in both (...) its original and a revised form (due to Iacoboni et al., 2005, 'Grasping the intentions of others with one's own mirror neuron system'), and argue that the existence of mirror neurons can in fact tell us very little about how intentional attribution actually proceeds. (shrink)

A “frame of reference” is a standard relative to which motion and rest may be measured; any set of points or objects that are at rest relative to one another enables us, in principle, to describe the relative motions of bodies. A frame of reference is therefore a purely kinematical device, for the geometrical description of motion without regard to the masses or forces involved. A dynamical account of motion leads to the idea of an “inertial frame,” or a reference (...) frame relative to which motions have distinguished dynamical properties. For that reason an inertial frame has to be understood as a spatial reference frame together with some means of measuring time, so that uniform motions can be distinguished from accelerated motions. The laws of Newtonian dynamics provide a simple definition: an inertial frame is a reference-frame with a time-scale, relative to which the motion of a body not subject to forces is always rectilinear and uniform, accelerations are always proportional to and in the direction of applied forces, and applied forces are always met with equal and opposite reactions. It follows that, in an inertial frame, the center of mass of a system of bodies is always at rest or in uniform motion. It also follows that any other frame of reference moving uniformly relative to an inertial frame is also an inertial frame. For example, in Newtonian celestial mechanics, taking the “fixed stars” as a frame of reference, we can determine an inertial frame whose center is the center of mass of the solar system; relative to this frame, every acceleration of every planet can be accounted for as a gravitational interaction with some other planet in accord with Newton 's laws of motion. (shrink)

Analysis of Emmy Noether’s 1918 theorems provides an illuminating method for testing the consequences of “coordinate generality”, and for exploring what else must be added to this requirement in order to give general covariance its far-reaching physical significance. The discussion takes us through Noether’s first and second theorems, and then a third related theorem due originally to F. Klein. Contact will also be made with the contributions of, principally, J.L. Anderson, A. Trautman, P.A.M. Dirac, R. Torretti and the father of (...) the whole business, A. Einstein (an apparent shift in Einstein’s thinking on the significance of general covariance between 1916 and 1918 is highlighted). (shrink)