"What in the ever-loving blue-eyed world do these [U1ano wicz's] innocuous comments on thermodynamics have to do with ecology!" Anonymous manuscript reviewer The American Naturalist, 1979 "The germ of the idea grows very slowly into something recognizable. It may all start with the mere desire to have an idea in the first place. " Walt Kelly Ten Ever-Lovin' Blue-Eyed Years with Pogo, 1959 "It all seems extremely interesting, but for the life of me it sounds as if you pulled it (...) out of the air," my good friend Ray Lassiter exclaimed to me after enduring about 20 minutes of my enthusiasm for the newly formu lated concept of "ascendency" in ecosystems. "It wasn't," I replied, "but it would take a book to show you where it came from. " If such was the reaction of someone usually sympathetic to my manner of thinking, what could I expect from those who viewed biological devel opment in the traditional way? After all, I was suggesting that it is possi ble to quantify the growth and development of an entire ecosystem. Fur thermore, I was maintaining that this development was not entirely determined by events and entities at smaller scales, and yet could influ ence these component processes and structures. To be sure, mine was only the latest of many challenges to straight reductionism, but, like everyone else with a new idea, I thought mine was special. (shrink)

The somatic mutation theory has been the prevailing paradigm in cancer research for the last 50 years. Its premises are: (1) cancer is derived from a single somatic cell that has accumulated multiple DNA mutations, (2) the default state of cell proliferation in metazoa is quiescence, and (3) cancer is a disease of cell proliferation caused by mutations in genes that control proliferation and the cell cycle. From this compelling simplicity, an increasingly complicated picture has emerged as more than 100 (...) oncogenes and 30 tumor suppressor genes have been identified. To accommodate this complexity, additional ad hoc explanations have been postulated. After a critical review of the data gathered from this perspective, an alternative research program has been proposed. It is based on the tissue organization field theory, the premises of which are that carcinogenesis represents a problem of tissue organization, comparable to organogenesis, and that proliferation is the default state of all cells. The merits of these competing theories are evaluated herein. BioEssays 26:1097–1107, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

A trait is robust to a genetic or environmental variable if its variation is weakly correlated with variation in that variable. The source of robustness lies in the fact that the developmental processes that give rise to complex traits are nonlinear. A consequence of this nonlinearity is that not all genes are equally correlated with the trait whose ontogeny they control. Here we explore how developmental mechanisms determine and alter the correlation structure between genes and the traits that they control. (...) A formula is developed by which the correlation of a gene or environmental variable with a trait can be calculated if the mechanism that gives rise to the trait is known. The nature of robustness and the ways in which robustness can evolve are discussed in the context of the problems that arise in the analysis of inherently nonlinear systems. BioEssays 24:553–563, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

In describing the flawless regularity of developmental processes and the correlation between changes at certain genetic loci and changes in morphology, biologists frequently employ two metaphors: that genes ‘control’ development, and that genomes embody ‘programs’ for development. Although these metaphors have an admirable sharpness and punch, they lead, when taken literally, to highly distorted pictures of developmental processes. A more balanced, and useful, view of the role of genes in development is that they act as suppliers of the material needs (...) of development and, in some instances, as context‐dependent catalysts of cellular changes, rather than as ‘controllers’ of developmental progress and direction. The consequences of adopting this alternative view of development are discussed. (shrink)

Development and Evolution surveys and illuminates the key themes of rapidly changing fields and areas of controversy that the redefining the theory and philosophy of biology. It continues Stanley Salthe's investigation of evolutionary theory, begun in his influential book Evolving Hierarchical Systems, while negating the implicit philosophical mechanisms of much of that work. Here Salthe attempts to reinitiate a theory of biology from the perspective of development rather than from that of evolution, recognizing the applicability of general systems thinking to (...) biological and social phenomena and pointing towards a non-Darwinian and even a postmodern biology. (shrink)

This book contains two lectures - given in 1988 and 1989 respectively - which belong to Karl Popper's late work, most of which is still unpublished. The first introduces a new view of causality, based on Popper's interpretation of quantum theory, yet freed of difficulty. It is a new view of the universe - a view that easily merges with the commonsense view that our will is free. The second lecture gives a glimpse of human knowledge as it evolves from (...) animal knowledge. Both lectures have been expanded by Popper for publication. (shrink)