This essay outlines the significance of understanding the relationship between Islam and science, particularly from the twentieth century onward. It mainly revolves around the viability of Darwin's evolutionary thought in the Muslim world, which is confronted by various groups of Muslim commentators and scholars. This study goes through various original sources, official documents, former unpublished theses, and Qur’ānic commentaries in Islamic languages from north Africa to the Malay‐Indonesian world to display the uninterrupted challenge of Muslims with European science in general (...) and European evolutionary thought in particular; an act which is not going to stop now, nor tomorrow. Finally, this essay aims to inform readers how a philosophical reading of Islam and science would be crucial before approving or rejecting any form of connection between the two, particularly in future. (shrink)