This essay examines the relationship between metabolic brain processes and psycho-physiological activities or mental activity. It is argued that metabolic brain processes, including those involved in the production of energy, proteins and other molecules are restorative and conditional, rather than directly involved in mental activities. This stance suggests that life-time acquired learning and memory is precipitated as a permanent and personal configuration of the brain, that is in principle accessible to neurophysiological examination. Current neuroscience largely ignores implicitly or explicitly the (...) search for new emergent configurations of the brain. (shrink)