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  1. I Miss Being Me: Phenomenological Effects of Deep Brain Stimulation.Frederic Gilbert, Eliza Goddard, John Noel M. Viaña, Adrian Carter & Malcolm Horne - 2017 - American Journal of Bioethics Neuroscience 8 (2):96-109.
    The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience of being implanted gives empirical and conceptual understanding of the potential phenomenon of DBS-induced self-estrangement. (...)
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  • Me, Myself and My Brain Implant: Deep Brain Stimulation Raises Questions of Personal Authenticity and Alienation.Felicitas Kraemer - 2011 - Neuroethics 6 (3):483-497.
    In this article, I explore select case studies of Parkinson patients treated with deep brain stimulation in light of the notions of alienation and authenticity. While the literature on DBS has so far neglected the issues of authenticity and alienation, I argue that interpreting these cases in terms of these concepts raises new issues for not only the philosophical discussion of neuro-ethics of DBS, but also for the psychological and medical approach to patients under DBS. In particular, I suggest that (...)
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  • Beyond Consent in Research.Emily Bell, Eric Racine, Paula Chiasson, Maya Dufourcq-Brana & Laura Macdonald - 2014 - Cambridge Quarterly of Healthcare Ethics 23 (3):361-368.
    Abstract:Vulnerability is an important criterion to assess the ethical justification of the inclusion of participants in research trials. Currently, vulnerability is often understood as an attribute inherent to a participant by nature of a diagnosed condition. Accordingly, a common ethical concern relates to the participant’s decisionmaking capacity and ability to provide free and informed consent. We propose an expanded view of vulnerability that moves beyond a focus on consent and the intrinsic attributes of participants. We offer specific suggestions for how (...)
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  • Brain, mind and machine: What are the implications of deep brain stimulation for perceptions of personal identity, agency and free will?Nir Lipsman & Walter Glannon - 2012 - Bioethics 27 (9):465-470.
    Brain implants, such as Deep Brain Stimulation (DBS), which are designed to improve motor, mood and behavioural pathology, present unique challenges to our understanding of identity, agency and free will. This is because these devices can have visible effects on persons' physical and psychological properties yet are essentially undetectable when operating correctly. They can supplement and compensate for one's inherent abilities and faculties when they are compromised by neuropsychiatric disorders. Further, unlike talk therapy or pharmacological treatments, patients need not ‘do’ (...)
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  • Deep Brain Stimulation and Postoperative Suicidality Among Treatment Resistant Depression Patients: Should Eligibility Protocols Exclude Patients with a History of Suicide Attempts and Anger/Impulsivity?Frédéric Gilbert - 2013 - American Journal of Bioethics Neuroscience 4 (1):28-35.
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  • Deep Brain Stimulation for Treatment Resistant Depression: Postoperative Feelings of Self-Estrangement, Suicide Attempt and Impulsive–Aggressive Behaviours.Frederic Gilbert - 2013 - Neuroethics 6 (3):473-481.
    The goal of this article is to shed light on Deep Brain Stimulation (DBS) postoperative suicidality risk factors within Treatment Resistant Depression (TRD) patients, in particular by focusing on the ethical concern of enrolling patient with history of self-estrangement, suicide attempts and impulsive–aggressive inclinations. In order to illustrate these ethical issues we report and review a clinical case associated with postoperative feelings of self-estrangement, self-harm behaviours and suicide attempt leading to the removal of DBS devices. Could prospectively identifying and excluding (...)
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  • Ethical Issues in Deep Brain Stimulation Research for Treatment-Resistant Depression: Focus on Risk and Consent.Laura B. Dunn, Paul E. Holtzheimer, Jinger G. Hoop, Helen S. Mayberg, Laura Weiss Roberts & Paul S. Appelbaum - 2011 - American Journal of Bioethics Neuroscience 2 (1):29-36.
    Deep brain stimulation (DBS) is currently in pivotal trials as an intervention for treatment-resistant depression (TRD). Although offering hope for TRD, DBS also provokes ethical concerns—particularly about decision-making capacity of people with depression—among bioethicists, investigators, institutional review boards, and the public. Here, we examine this critical issue of informed consent for DBS research using available evidence regarding decision-making capacity and depression. Further, we explore the implications of the nature of TRD as well as that of the intervention (invasive brain surgery) (...)
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  • Deep Brain Stimulation Research Protocols and Depressive Patients with Previous Suicidality: We Can't Afford to Lose Focus.Andrew Coulter - 2013 - American Journal of Bioethics Neuroscience 4 (1):41-42.
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  • Beyond Consent in Research.Emily Bell, Eric Racine, Paula Chiasson, Maya Dufourcq-Brana, Laura B. Dunn, Joseph J. Fins, Paul J. Ford, Walter Glannon, Nir Lipsman, Mary Ellen Macdonald, Debra J. H. Mathews & Mary Pat Mcandrews - 2014 - Cambridge Quarterly of Healthcare Ethics 23 (3):361-368.
    Abstract:Vulnerability is an important criterion to assess the ethical justification of the inclusion of participants in research trials. Currently, vulnerability is often understood as an attribute inherent to a participant by nature of a diagnosed condition. Accordingly, a common ethical concern relates to the participant’s decisionmaking capacity and ability to provide free and informed consent. We propose an expanded view of vulnerability that moves beyond a focus on consent and the intrinsic attributes of participants. We offer specific suggestions for how (...)
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  • The Complexity of Deep Brain Stimulation and Suicidality in Patients with Treatment Resistant Depression.Brian S. Appleby - 2013 - American Journal of Bioethics Neuroscience 4 (1):39-40.
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