Race or ethnic identity, despite its imprecise categorization, is a useful means of identifying population differences in mechanisms of disease and treatment effects. Therefore, race and other arbitrary demographic and physiological variables have appropriately served as a helpful guide to clinical management and to clinical trial participation. The African-American Heart Failure Trial was carried out in African-Americans with heart failure because prior data had demonstrated a uniquely favorable effect in this subpopulation of the drug combination in BiDil. The remarkable effect (...) of the drug in reducing mortality in this study has illuminated an important new mechanism of therapy for heart failure. Application of these findings need not be confined to the population studied, but the observation highlights the need for more precise ways to identify individual responsiveness to therapy. (shrink)

The use of racial categories in biomedicine has had a long history in the United States. However, social hierarchy and discrimination, justified by purported scientific differences, has also plagued the history of racial categories. Because “race” has some correlation with biological and genetic characteristics, there has been a call not to “throw the baby out with the bathwater” by eliminating race as a research or clinical category. I argue that race is too undefined and fluid to be useful as a (...) proxy for biology or genetics. (shrink)

The idea that genuinely racial thinking is a modern invention is widespread in the humanities and social sciences. However, it is not always clear exactly what the content of such a conceptual break is supposed to be. One suggestion is that with the scientific revolution emerged a conception of human groups that possessed essences that were thought to explain group-typical features of individuals as well the accumulated products of cultures or civilizations. However, recent work by cognitive and evolutionary psychologists suggests (...) that such essentialism is a product of culturally canalized, domain-specific, and species-typical features of human psychology. This suggests that one common explanation of the content of a break in racial thinking is wrong, and casts some doubt on the thesis that genuinely racial thinking is a culturally and historically local invention. (shrink)