The Protestant Reformation is one of the greatest turning points in the history of Christianity. In some senses, it is described as a ‘theological revolution’ which led to the emergence of the Protestant movement and the separation of the Church. This research explores some of the theological themes that became the turning point of Christianity. These themes are sola scriptura, sola fide, sola gratia, solus Christus and Soli Deo Gloria. This article attempts to briefly explore these essential theological principles of (...) the Reformation and assess its relevance for today in light of new realities, encounters and theological developments. It pays particular attention to the realities of the Global South, mainly South Africa, and shows how these can form a basis for renewal and transformation of Reformed theology and practice today. In this sense, the article establishes that the ‘theological revolution’ continues into the 21st century bringing about ecclesiastical, social and cultural change. (shrink)