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  1. Ecological Models for Gene Therapy. II. Niche Construction, Nongenetic Inheritance, and Ecosystem Perturbations.Arnaud Pocheville, Maël Montévil & Régis Ferrière - 2014 - Biological Theory 9 (4):414-422.
    In this paper, we apply the perspective of intra-organismal ecology by investigating a family of ecological models suitable to describe a gene therapy to a particular metabolic disorder, the adenosine deaminase deficiency (ADA-SCID). The gene therapy is modeled as the prospective ecological invasion of an organ (here, bone marrow) by genetically modified stem cells, which then operate niche construction in the cellular environment by releasing an enzyme they synthesize. We show that depending on the chosen order (a choice that cannot (...)
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  • A 2-dimensional geometry for biological time.Francis Bailly, Giuseppe Longo & Maël Montévil - 2011 - Progress in Biophysics and Molecular Biology 106:474 - 484.
    This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of life, such as rhythms, both physical (circadian, seasonal …) and properly biological (heart beating, respiration, metabolic …). In particular, the role of biological rhythms do not seem to have any counterpart in mathematical formalization of physical clocks, which are based on frequencies along the usual (...)
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  • Ni Dieu ni gène: pour une autre théorie de l'hérédité.Jean-Jacques Kupiec & Pierre Sonigo - 2000
    Qu'est-ce qu'une espèce? Comment se développe un embryon? Comment comprendre l'obésité, le cancer ou le sida? Les progrès de la biologie moléculaire nous ont persuadés que, tel un démiurge tout puissant, le génome crée l'organisme et en constitue l'explication ultime. Deux chercheurs montrent ici, de la molécule à l'Homme, en passant par les cellules et les virus, que règne moins la dictature d'un dieu-programme inscrit dans l'ADN qu'un hasard permanent, guidé par la sélection naturelle. Nous ne sommes plus, depuis Copernic, (...)
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  • Ecological Orbits: How Planets Move and Populations Grow.Lev Ginzburg & Mark Colyvan - unknown
    The main focus of the book is the presentation of the 'inertial' view of population growth. This view provides a rather simple model for complex population dynamics, and is achieved at the level of the single species without invoking species interactions. An important part of this account is the maternal effect. Investment of mothers in the quality of their daughters makes the rate of reproduction of the current generation depend not only on the current environment, but also on the environment (...)
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  • Vorträge über die Descendenztheorie, gehalten an der Universität zu Freiburg im Breisgau. [REVIEW]August Weismann - 1903 - Ancient Philosophy (Misc) 13:318.
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