Especially troublesome in this dispute is the status of the natural sciences, and this is where Hacking finds some of his most telling cases, from the conflict ...

The disease construction of schizophrenia is no longer tenable. That construction originated during a period of rapid growth of biological science based on mechanistic principles. Crude diagnostis measures failed to differentiate absurd, unwanted conduct due to biological conditions from atypical conduct directed to solving existential or identity problems. The construction was communicated - in the absence of solid evidence - by medical practitioners by means of symbolic, rhetorical, and organizational acts. The patient came to be regarded as an object without (...) agency or goals. In spite of enormous research funding, no biological or psychological marker has been discovered that would differentiate diagnosed schizophrenics from normals without creating unacceptable proportions of false positives and false negatives. Employing a moral category, "unwanted conduct," as a criterion, and tacitly transforming moral judgments to the medical category, schizophrenia, leads to the use of schizophrenia/nonschizophrenia as the independent variable in research designs. The failure of eight decades of research to produce a reliable marker leads to the conclusion that schizophrenia is an obsolescent hypothesis and should be abandoned. (shrink)