Popper formulates and explains his non-justificationist theory of knowledge. Science--empirical science--aims at true explanatory theories, yet it can never prove, finally establish, or justify any of its theories as true, not even if it is in fact a true theory. Science must continue to question and criticize all its theories, even those which happen to be true.

The metaphysical commitments of quantum field theory are examined. A thesis of underdetermination as between field and particle approaches to the "elementary particles" is argued for but only if a disputed notion of transcendental individuality is admitted. The superiority of the field approach is further emphasized in the context of heuristics.

The basic theme of Popper's philosophy--that something can come from nothing--is related to the present situation in physical theory. Popper carries his investigation right to the center of current debate in quantum physics. He proposes an interpretation of physics--and indeed an entire cosmology--which is realist, conjectural, deductivist and objectivist, anti-positivist, and anti-instrumentalist. He stresses understanding, reminding us that our ignorance grows faster than our conjectural knowledge.