This essay attempts a restatement of the relationship between art and science in terms of “making” and “knowing.” It first surveys the various ways art and science were related in the early modern period, arguing that one result of the new naturalistic representation was the emergence of a new visual culture that reinforced appeals to eyewitness and firsthand experience and in some cases fostered a new examination of European culture. At the same time, art, understood as the work of the (...) human hand in imitating nature, came to be viewed as one of the central characteristics that distinguished European society from the past. Moreover, artist/artisans helped constitute the aims and methods of the study of nature during the fifteenth and sixteenth centuries, articulating a new kind of authority for nature and providing the artworks that engendered a culture of nature study and collection. Thus art and artisans were fundamental motors of the Scientific Revolution. More attention to the visual culture of early modern Europe, including religious and devotional imagery, and seeking out intersections between making and knowing, as some art historians studying techniques have begun to do, will add to our understanding of the relationship between art and science in the early modern period. (shrink)