Recent discussions of civil disobedience show the world of scholarship and public affairs in disarray. Not only is there considerable disagreement over how civil disobedience is to be justified, there is hardly less disagreement over what civil disobedience is. Can it be violent, or must it be nonviolent, in intention and in outcome? Can civil disorder be a special case of mass civil disobedience? Must civil disobedience proceed within the framework of the existing politico-legal system or may it be revolutionary (...) in intention? Could it be anarchistic? Should the authorities endeavor to prosecute and punish the civil disobedient as though he were a common criminal? Is disobedience which results in no punishment of the disobedient not civil disobedience after all? Because of disagreements over the answers to these questions, the description of an act as an act of civil disobedience is likely to be ambiguous and controversial not only for the general public and the government but even in some cases for the protesters themselves. Confusion rooted in honest misunderstanding is compounded by bad faith, by basic disagreements over the ideal and the actual relations between the individual and the state, and by obscurity in the facts surrounding the intentions of the protesters and the consequences of their acts. (shrink)

What makes a cell? How are cells able to replicate themselves in a stable manner? How did cellular life emerge on our planet? The answer to these fundamental questions lies at the base of biology. Cellular life is the basic unit of living organization and defines the presence of a stable information reservoir connected through the external world by a well-defined boundary. Inside the cell, chains of computations and chemical reactions take place, sustained by self-assembled molecular machines. At the cell (...) membrane, the environment and the cell communicate with each other through proteins that are able to detect small concentration changes and send the appropriate signals. But modern cells are very sophisticated entities and extracting the logic of cell organization from them is a gigantic effort. In order to answer these questions, we need to look at cells in a more basic level: a reduction of complexity is needed. Protocells, roughly defined as the simplest instances of autonomous cell-like structures, have been a matter of exploration for decades. Although most of the original work in this area was largely theoretical, the end of the twentieth century was marked by very active experimental research on minimal cells. One approach has been the top-down strategy, where living organisms (the simplest life forms) are being selectively modified to reduce their genome complexity. Such a minimal genome would be the smallest one able to sustain reproduction and growth under a given set of external constraints (mainly available molecules). The second approach is the bottom-up one, very much in the tradition of research into the origins of life. Under this approach, extremely simple life forms are built from basic chemical components, including lipids and a basic.. (shrink)