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  1. Size assessment and growth control: how adult size is determined in insects.Christen Kerry Mirth & Lynn M. Riddiford - 2007 - Bioessays 29 (4):344-355.
    Size control depends on both the regulation of growth rate and the control over when to stop growing. Studies of Drosophila melanogaster have shown that insulin and Target of Rapamycin (TOR) pathways play principal roles in controlling nutrition‐dependent growth rates. A TOR‐mediated nutrient sensor in the fat body detects nutrient availability, and regulates insulin signaling in peripheral tissues, which in turn controls larval growth rates. After larvae initiate metamorphosis, growth stops. For growth to stop at the correct time, larvae need (...)
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  • Phenotypic Evolution: A Reaction Norm Perspective.Carl Schlichting & Massimo Pigliucci - 1998 - Sinauer.
    Phenotypic Evolution explicitly recognizes organisms as complex genetic-epigenetic systems developing in response to changing internal and external environments. As a key to a better understanding of how phenotypes evolve, the authors have developed a framework that centers on the concept of the Developmental Reaction Norm. This encompasses their views: (1) that organisms are better considered as integrated units than as disconnected parts (allometry and phenotypic integration); (2) that an understanding of ontogeny is vital for evaluating evolution of adult forms (ontogenetic (...)
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