Facts often acquire a life of their own; the stories in this book explain why.

Historians of molecular biology have paid significant attention to the role of scientific instruments and their relationship to the production of biological knowledge. For instance, Lily Kay has examined the history of electrophoresis, Boelie Elzen has analyzed the development of the ultracentrifuge as an enabling technology for molecular biology, and Nicolas Rasmussen has examined how molecular biology was transformed by the introduction of the electron microscope (Kay 1998, 1993; Elzen 1986; Rasmussen 1997). 1 Collectively, these historians have demonstrated how instruments (...) and other elements of the material culture of the laboratory have played a decisive role in determining the kind and quantity of .. (shrink)

In recent years, historians have debated the prospect of offering new ‘transnational’ or ‘global’ perspectives in their studies. This paper introduces the reader to this special issue by analysing characteristics, merits and flaws of these approaches. It then considers how historians of science have practised transnational history without, however, paying sufficient attention to the theoretical foundations of this approach. Its final part illustrates what benefits may derive from the application of transnational history in the field. In particular, we suggest looking (...) at the construction of transnational networks in science, and discuss some of the methodological consequences of adopting this approach. (shrink)

I am honored to have been invited to participate in this Workshop on Comparative Studies of Building Molecular Biology, with a discussion of Japanese experiences in constructing a science — in this case, the discipline of molecular biology. As I understand it, the construction of a science must be equivalent to building a new culture. My having given this title to my paper suggests that I have enough knowledge about the subject to perhaps even extrapolate its course into the future (...) — which I do not. What I do have is a sincere admiration of my old friends and colleagues, in Japan and elsewhere, who together tried to build a new science of molecular biology in Japan. (shrink)

This article proposes a new bi-directional way of understanding the convergence of biology and computing. It argues for a reciprocal interaction in which biology and computing have shaped and are currently reshaping each other. In so doing, we qualify both the view of a natural marriage and of a digital shaping of biology, which are common in the literature written by scientists, STS, and communication scholars. The DNA database is at the center of this interaction. We argue that DNA databases (...) are spaces of convergence for computing and biology that change in form, meaning, and function from the 1960s to the 2000s. The first part of the article shows how, in the 1980s, DNA sequencing shifted from passively incorporating computers to be increasingly modeled in digital coding and decoding. Information retrieval algorithms, reciprocally, were altered according to the peculiarities of DNA in the first sequence-storage databases. The second part of the article investigates the impact of these reciprocal interactions and globalization on the organization of research centers, ways of conducting big science, and scientific values. Through convergence and new technologies such as data mining, biology and computing were transformed technologically, institutionally, and culturally into a new bio-data enterprise called genomics. (shrink)