There are two intriguing paradoxes in molecular biology-the inconsistent relationship between organismal complexity and (1) cellular DNA content and (2) the number of protein-coding genes-referred to as the C-value and G-value paradoxes, respectively. The C-value paradox may be largely explained by varying ploidy. The G-value paradox is more problematic, as the extent of protein coding sequence remains relatively static over a wide range of developmental complexity. We show by analysis of sequenced genomes that the relative amount of non-protein-coding sequence increases (...) consistently with complexity. We also show that the distribution of introns in complex organisms is non-random. Genes composed of large amounts of intronic sequence are significantly overrepresented amongst genes that are highly expressed in the nervous system, and amongst genes downregulated in embryonic stem cells and cancers. We suggest that the informational paradox in complex organisms may be explained by the expansion of cis-acting regulatory elements and genes specifying trans-acting non-protein-coding RNAs. (shrink)

Recently, several philosophers have challenged the view that evolutionary theory is usefully understood by way of an analogy with Newtonian mechanics. Instead, they argue that evolutionary theory is merely a statistical theory. According to this alternate approach, natural selection and random genetic drift are not even causes, much less forces. I argue that, properly understood, the Newtonian analogy is unproblematic and illuminating. I defend the view that selection and drift are causes in part by attending to a pair of important (...) distinctions—that between process and product and that between natural selection and fitness. (shrink)

Resolution of the entropy‐evolution problem was a significant issue for Pierre Teilhard de Chardin throughout his scientific career. Although never truly satisfied with his solution, he proposed that all energy must be psychic and contain two components. Tangential energy is related to physical energy. Radial energy in some way accounts for increasing complexity and consciousness in evolution. Analysis of developments in thermodynamics, statistical mechanics, and information theory show that Gibbs free energy contains both calorimetric and noetic components, thus validating Teilhard's (...) intuition. (shrink)

Anselm's Ontological Argument fails, but not for any of the various reasons commonly adduced. In particular, its failure has nothing to do with violating deep Kantian principles by treating ‘exists’ as a predicate or making reference to ‘Meinongian’ entities. Its one fatal flaw, so far from being metaphysically deep, is in fact logically shallow, deriving from a subtle scope ambiguity in Anselm's key phrase. If we avoid this ambiguity, and the indeterminacy of reference to which it gives rise, then his (...) argument is blocked even if his supposed Meinongian extravagances are permitted. Moreover it is blocked in a way which is straightforward and compelling (by contrast with the Kantian objections), and which generalizes easily to other versions of the Ontological Argument. A significant moral follows. Fear of Anselm's argument has been hugely influential in motivating ontological fastidiousness and widespread reluctance to countenance talk of potentially non-existing entities. But if this paper is correct, then the Ontological Argument cannot properly provide any such motivation. Some of the most influential contributions to ontology, from Kant to Russell and beyond, rest on a mistake. (shrink)

There has recently been a renewed interest in the “force” interpretation of evolutionary biology. In this article, I present the general structure of the arguments for the force interpretation and identify a problem in its overly permissive conditions for being a Newtonian force. I then attempt a solution that (1) helps to illuminate the difference between forces and other types of causes and (2) makes room for random genetic drift as a force. In particular, I argue that forces are not (...) different in kind from other types of causes but rather that forces are situated on a continuum of causes distinguished by their unifying power. †To contact the author, please write to: Department of Philosophy, University of Wisconsin–Madison, 5185 Helen C. White Hall, Madison, WI 53706; e‐mail: [email protected]. (shrink)

The received view of Bergson's philosophy of life is that it advances some form of vitalism under the heading of an “élan vital.” This paper argues against the vitalistic interpretation of Bergson's élan vital as it appears in Creative Evolution in favor of an interpretation based on his overlooked reflections on entropy and energetics. Within the interpretation developed here, the élan vital is characterized not as a spiritualistic “vital force” but as a tendency of organization opposed to the tendency of (...) entropic degradation. It is then shown how Bergson's view of evolution and living organization resonates with more contemporary scientific approaches belonging to a “thermodynamic paradigm” in theoretical biology in different respects, including the critique of neo-Darwinism and the positing of a driving force behind evolution. Finally, the special interest that Bergson's philosophical biology bears today is considered in terms of the connection between the concepts of élan vital and duration. (shrink)

Buddhist philosophy asserts that human suffering is caused by ignorance regarding the true nature of reality. According to this, perceptions and thoughts are largely fabrications of our own minds, based on conditioned tendencies which often involve problematic fears, aversions, compulsions, etc. In Buddhist psychology, these tendencies reside in a portion of mind known as Store consciousness. Here, I suggest a correspondence between this Buddhist Store consciousness and the neuroscientific idea of stored synaptic weights. These weights are strong synaptic connections built (...) in through experience. Buddhist philosophy claims that humans can find relief from suffering through a process in which the Store consciousness is transformed. Here, I argue that this Buddhist 'transformation at the base' corresponds to a loosening of the learned synaptic connections. I will argue that Buddhist meditation practices create conditions in the brain which are optimal for diminishing the strength of our conditioned perceptual and behavioural tendencies. (shrink)