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  1. Impossibility: the limits of science and the science of limits.John D. Barrow - 1998 - New York: Oxford University Press.
    John Barrow is increasingly recognized as one of our most elegant and accomplished science writers, a brilliant commentator on cosmology, mathematics, and modern physics. Barrow now tackles the heady topic of impossibility, in perhaps his strongest book yet. Writing with grace and insight, Barrow argues convincingly that there are limits to human discovery, that there are things that are ultimately unknowable, undoable, or unreachable. He first examines the limits on scientific inquiry imposed by the deficiencies of the human mind: our (...)
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  • Verification, Validation, and Confirmation of Numerical Models in the Earth Sciences.Naomi Oreskes, Kristin Shrader-Frechette & Kenneth Belitz - 1994 - Science 263 (5147):641-646.
    Verification and validation of numerical models of natural systems is impossible. This is because natural systems are never closed and because model results are always nonunique. Models can be confirmed by the demonstration of agreement between observation and prediction, but confirmation is inherently partial. Complete confirmation is logically precluded by the fallacy of affirming the consequent and by incomplete access to natural phenomena. Models can only be evaluated in relative terms, and their predictive value is always open to question. The (...)
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  • Priors and prejudice.R. E. G. Upshur - 1999 - Theoretical Medicine and Bioethics 20 (4):319-327.
    This paper explores the relationship between concepts of probability and hermeneutics. It seeks to examine the relationship between subjective (Bayesian) views of probability and hermeneutic descriptions of understanding. It is argued that Gadamer'saccount of the prejudicial nature of understanding, derived from Heidegger'sanalysis of foreunderstanding, offers a provocative model of clinical reasoning. The implications of this model for evidence-based medicine are discussed in conclusion.
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  • Remembering the goals of medicine.Daniel Callahan - 1999 - Journal of Evaluation in Clinical Practice 5 (2):103-106.
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  • Underdetermination and incommensurability in contemporary epidemiology.Douglas L. Weed - 1997 - Kennedy Institute of Ethics Journal 7 (2):107-124.
    In the shadowy world between philosophy of science and ethics lie the paired concepts of underdetermination and incommensurability. Typically, scientific evidence underdetermines the hypotheses tested in research studies, providing neither proof nor disproof. As a result, scientists must judge the weight of the evidence, and in doing so, bring scientific and extrascientific values to bear in their approaches to assessing and interpreting the evidence. When different scientists employ very different values, their views are said to be incommensurable. Less prominent differences (...)
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