A model of the neuropsychology of anxiety is proposed. The model is based in the first instance upon an analysis of the behavioural effects of the antianxiety drugs in animals. From such psychopharmacologi-cal experiments the concept of a “behavioural inhibition system” has been developed. This system responds to novel stimuli or to those associated with punishment or nonreward by inhibiting ongoing behaviour and increasing arousal and attention to the environment. It is activity in the BIS that constitutes anxiety and that (...) is reduced by antianxiety drugs. The effects of the antianxiety drugs in the brain also suggest hypotheses concerning the neural substrate of anxiety. Although the benzodiazepines and barbiturates facilitate the effects of γ-aminobutyrate, this is insufficient to explain their highly specific behavioural effects. Because of similarities between the behavioural effects of certain lesions and those of the antianxiety drugs, it is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system, the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures. Analysis of the functions of this system suggests that it acts as a comparator: it compares predicted to actual sensory events and activates the outputs of the BIS when there is a mismatch or when the predicted event is aversive. Suggestions are made as to the functions of particular pathways within this overall brain system. The resulting theory is applied to the symptoms and treatment of anxiety in man, its relations to depression, and the personality of individuals who are susceptible to anxiety or depression. (shrink)

Mere exposure, generally, entails influences of familiarity manipulations on affective dependent variables. Previously (Phaf & Rotteveel, 2005), we have argued that familiarity corresponds intrinsically to positive affect, and have extended the correspondence to novelty and negative affect. Here, we present two experiments that show reverse effects of affective manipulations on perceived familiarity. In Experiment 1 affectively valenced exteroceptive cues of approach and avoidance (e.g., apparent movement) modulated recognition bias of neutral targets. This finding suggests that our correspondence hypotheses can be (...) generalised to an important aspect of emotion, namely approach and avoidance tendencies. In Experiment 2 participants? emotional mood was manipulated within the Jacoby?Whitehouse paradigm and a pattern of results was obtained as if consciousness was manipulated. We interpret the latter results within the affective modulation framework (AMF), which postulates facilitation of nonconscious processing by positive affect and an enhancement of conscious processing by negative affect. (shrink)