During meditation, consciousness/awareness is usually enhanced because of higher attention and concentration, which inter-dependently co-arise thru appropriate interactions between neural signals. Nāgārjuna rejects ‘inherent existence’ or ‘essence’ in favor of co-dependent origination (Pratītyasamutpāda), and that is also why he rejects causality; the entities that lack inherent existence dependently co-arise. Causality is a major issue in metaphysical views. The goals of this article are as follows: (I)Which entities lack ‘inherent existence’ or ‘essence’ and which ones inherently exist? (II) Do the entities (...) that lack inherent existence dependently co-arise and hence can we reject causality as in Nāgārjuna’s philosophy? (III) Do the entities that exist inherently cause entities that lack inherent existence? (IV) Do structure, function, experience, and environment cause each other? And (V)We critically analyze, extend, and examine Nāgārjuna’s philosophy of dependent co- origination in the extended Dual-Aspect Monism (eDAM) framework. Our analysis suggests that: (i) All conventional entities lack inherent existence. However, the dual-aspect unmanifested state of the primal entity (unified information field (UIF), emptiness, Śūnyatā, a neutral entity of Neutral Monism, or Brahman) inherently exists. The dual-aspect unmanifested state of UIF has (a) physical unified information field (PUIF, quantum vacuum, ‘zero- point field’/ZPF)as physical aspect and (b) unified potential consciousness information field (UPCIF) as the non-physical aspect. The subjective experiences (SEs) of objects and of the subject (self) are the excitations or modes of the UPCIF, so they are derived entities and hence they lack inherent existence. The dual-aspect unmanifested state of UIF/emptiness/Śūnyatā is fundamental and irreducible, and hence it inherently exists. (ii) The entities that lack inherent existence dependently co-arise, and hence causality for them can be rejected but instead conditions (such as efficient, percept-object, immediate, and dominant conditions) are necessary, as in Nāgārjuna’s philosophy. (iii) It is unclear that the dual-aspect primal entity UIF (Brahman/emptiness/Śūnyatā) that exists inherently cause entities that lack inherent existence. Most likely, all manifested entities inter-dependently co-arise thru natural laws built-in the UIF when necessary conditions for a manifested entity are satisfied thru interaction among relevant entities. (iv) It is unclear that structure, function, experience, and environment cause each other. A cause must, at the same time, be an effect of another cause. This implies that there is no first cause. Therefore, the structure, function, and experience inter-dependently co-arise thru co-evolution, co-development, sensorimotor co-tuning, and the interaction among relevant entities after the necessary conditions of manifestation of a specific entity are satisfied; and they are linked via conditions. (v) In the extended Dual-Aspect Monism (eDAM) framework, the physical aspect of a state of a manifested entity and that of the non-physical aspect (with functional, qualitative, cognitive, and experiential sub-aspects) of the same state of the same entity inseparably co-exist in each state of each entity at all levels. However, the degrees of manifestations of inseparable physical and non-physical aspects vary with the states, levels of entities, and contexts. Moreover, manifested entities lack inherent existence. In other words, the physical aspect and that of the non-physical aspect of manifested entities dependently co- arise, co-evolve, co-develop, and co-tuned for sensorimotor system appropriately depending on the levels of entities and contexts, which along with common “effective”information entail the inseparability of both aspects. In this sense, the symmetry between physical and non-physical aspects of a state of an entity (such as brain-mind system) is maintained, where the physical aspect (from third person perspective) does not cause the inseparable non-physical aspect (from first-person perspective) in living systems or vice- versa. (shrink)