Schiff base ligands and their metal complexes are considered promising leads in the development of new drugs. Due to their outstanding ability to form chelate complexes, they readily interact with transition metals that possess vacant orbitals. Several benefits are associated with transition metal complexes due to their favorable biocompatibility and low toxicity in biological systems. This study seeks to investigate the synthesis of a novel Schiff base derived from two starting materials: p-anisaldehyde and cefuroxime. The p-anisalce-furoxime complex was synthesized by (...) coordinating it with metal ions of Cu2+ and Fe2+, resulting in the formation of new metal complexes. The antibacterial properties of these compounds were examined against gram-positive and gram-negative bacterial strains. These synthesized compounds were characterized using infrared spectroscopy (IR), nuclear magnetic resonance (NMR) spectroscopy 1H NMR, 13C NMR and UV spectral data, along with melting point measurement, chemical testing, thin-layer chromatography (TLC) analysis, colour testing, and solubility assessments, etc. Molecular docking analysis was concluded by docking SB ligands with PBP2x of Streptococcus pneumoniae, revealing the binding affinity of the SB ligand. The pharmacokinetic parameters of the SB ligand were studied using online web tools such as Swiss absorption, distribution, metabolism, and excretion (ADME), pkCSM, and admetSAR. Thus, the synthesized Schiff base ligand and its metal complexes exhibit significant antibacterial activity and promising pharmacokinetic properties, making them strong candidates for further development as antibacterial agents. (shrink)

Cattle farming is a traditional agricultural system that contributes to the rural economic, social, and cultural values of the communities. Cattle as common with other livestock, are affected by many diseases that cause mortality and economic losses. In many rural households, the use of plants and associated knowledge are popular for managing cattle diseases, especially in areas experiencing challenges with conventional veterinary medicine. Evidence on the documentation of indigenous knowledge and biological evaluation of plants used against cattle diseases remain understudied (...) and fragmented. The aim of the review is to collate and analyze the ethnoveterinary knowledge and biological evaluation of plants used against cattle diseases in South Africa. Different scientific databases were systematically explored to extract data from 37 eligible studies. A total of 310 medicinal plants from 81 families were used to treat 10 categories of cattle diseases across seven (7) provinces in South Africa. Leguminosae (Fabaceae), Compositae (Asteraceae), Asparagaceae, and Xanthorrhoeaceae were the most frequently used plant families. Common plant parts used were leaves and roots. Twenty-seven (27) combination remedies involving 2–6 plants were identified as treatment regimes against cattle diseases. Common preparation methods were infusion and decoction while the administration mode was predominantly unspecified (52%) while oral and topical contributed 26 and 22%, respectively. In terms of diseases, the most treated ones were general systems infection, reproduction disorders, and gastrointestinal problems. Currently, an estimated 21% of the 310 plants have been evaluated for diverse biological activities using relevant bioassays related to cattle diseases. Antibacterial activity remained the most studied biological activity. Evidence from the review revealed the significance of ethnoveterinary medicine against cattle diseases especially in rural areas of South Africa. Nevertheless, the use of plants for cattle diseases among other ethnic groups, particularly in the Northern Cape and Western Cape, remains understudied. (shrink)

Solanum melongena (Eggplant) is a medicinal plant belonging to the family Solanaceae. This study aimed to perform a comparative assessment of the methanol extracts of the fruit and the leaf of Solanum melongena against multi-drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The crude extracts were obtained from the leaves and fruits of the plant using methanol. The plant extracts were tested for the presence of various phytochemical constituents qualitatively. The antibacterial assay and minimum inhibitory concentration for the crude extracts were (...) carried out using the agar well diffusion and agar dilution methods, respectively. Phytochemical analysis of methanol extracts of Solanum melongena revealed the presence of various phytoconstituents. Antibacterial assay of methanol extracts of Staphylococcus melongena against multi-drug-resistant Staphylococcus aureus isolates with ciprofloxacin as a reference control revealed inhibition zone diameter ranging from 04.0±0.0 to 11.0±0.0 mm; in contrast that of multi-drug-resistant Pseudomonas aeruginosa isolates revealed inhibition zone diameter, with ciprofloxacin showing no inhibition. The minimum inhibitory concentration of the methanol extracts on Pseudomonas aeruginosa isolates ranges from 25.0 to 50.0 mg/ml and 25.0->50.0 mg/ml, respectively, in comparison, the minimum inhibitory concentration of the methanol extracts on Staphylococcus aureus isolates ranges from 6.25 to 50.0 mg/ml and 6.25->50.0 mg/ml respectively. Thus, the fruit extract had better activity against test multi-drug-resistant Pseudomonas aeruginosa and Staphylococcus aureus than the leaf extract of Solanum melongena. (shrink)

Since the beginning of recorded history, Curcuma longa has been valued for its medicinal benefits as a root crop. Turmeric's phytochemicals, which include curcuminoids, essential oils, and other bioactive substances, are principally responsible for its therapeutic effects. The Phytochemistry of Curcuma longa is described in this narrative review, with special attention paid to the major classes of phytochemicals and their potential for medicinal use. The therapeutic properties of the curcuminoids, particularly curcumin, as well as their potential to prevent and cure (...) a variety of chronic disorders have all been thoroughly investigated. Turmeric possesses a variety of bioactive chemicals, which include turmerones and polysaccharides, which have shown to have important pharmacological effects, such as antibacterial, anticancer, and hepatoprotective properties. The antibacterial and antifungal qualities of turmeric’s essential oils have also been proved. Promising results have been found in studies looking at the phytochemical potential of Curcuma longa, and investigations into its medicinal uses are still ongoing. The objective of this study is to give a thorough review of what is currently known regarding the Phytochemistry & therapeutic potential of this valuable plant. (shrink)

Solanum melongena (Eggplant) is a medicinal plant belonging to the family Solanaceae. This study aimed to perform a comparative assessment of the methanol extracts of the fruit and the leaf of Solanum melongena against multi-drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The crude extracts were obtained from the leaves and fruits of the plant using methanol. The plant extracts were tested for the presence of various phytochemical constituents qualitatively. The antibacterial assay and minimum inhibitory concentration for the crude extracts were (...) carried out using the agar well diffusion and agar dilution methods, respectively. Phytochemical analysis of methanol extracts of Solanum melongena revealed the presence of various phytoconstituents. Antibacterial assay of methanol extracts of Staphylococcus melongena against multi-drug-resistant Staphylococcus aureus isolates with ciprofloxacin as a reference control revealed inhibition zone diameter ranging from 04.0±0.0 to 11.0±0.0 mm; in contrast that of multi-drug-resistant Pseudomonas aeruginosa isolates revealed inhibition zone diameter, with ciprofloxacin showing no inhibition. The minimum inhibitory concentration of the methanol extracts on Pseudomonas aeruginosa isolates ranges from 25.0 to 50.0 mg/ml and 25.0->50.0 mg/ml, respectively, in comparison, the minimum inhibitory concentration of the methanol extracts on Staphylococcus aureus isolates ranges from 6.25 to 50.0 mg/ml and 6.25->50.0 mg/ml respectively. Thus, the fruit extract had better activity against test multi-drug-resistant Pseudomonas aeruginosa and Staphylococcus aureus than the leaf extract of Solanum melongena. (shrink)